Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

Sonja Krane; So Ra Kim; Leif M. Abrell; Koji Nakanishi

doi:10.1002/hlca.200390319

Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

Sonja Krane, So Ra Kim, Leif M. Abrell, Koji Nakanishi

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.

Original language	English (US)
Pages (from-to)	3776-3786
Number of pages	11
Journal	Helvetica Chimica Acta
Volume	86
Issue number	11
DOIs	https://doi.org/10.1002/hlca.200390319
State	Published - 2003
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Biochemistry
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Access to Document

10.1002/hlca.200390319

Cite this

@article{2aa8ffbff8024f4db0b2017e86888d5c,

title = "Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides",

abstract = "Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.",

author = "Sonja Krane and Kim, {So Ra} and Abrell, {Leif M.} and Koji Nakanishi",

year = "2003",

doi = "10.1002/hlca.200390319",

language = "English (US)",

volume = "86",

pages = "3776--3786",

journal = "Helvetica Chimica Acta",

issn = "0018-019X",

publisher = "Wiley-Blackwell",

number = "11",

}

TY - JOUR

T1 - Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

AU - Krane, Sonja

AU - Kim, So Ra

AU - Abrell, Leif M.

AU - Nakanishi, Koji

PY - 2003

Y1 - 2003

N2 - Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.

AB - Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.

UR - http://www.scopus.com/inward/record.url?scp=0346752023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346752023&partnerID=8YFLogxK

U2 - 10.1002/hlca.200390319

DO - 10.1002/hlca.200390319

M3 - Article

AN - SCOPUS:0346752023

SN - 0018-019X

VL - 86

SP - 3776

EP - 3786

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 11

ER -

Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this