Abstract
A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray results were confirmed by specific polymerase chain reaction and serological analysis for HPIV-4. Conventional clinical laboratory testing using an extensive panel of microbiological tests failed to yield a diagnosis. This case suggests that the potential severity of disease caused by HPIV-4 in adults may be greater than previously appreciated and illustrates the clinical utility of a microarray for broad-based viral pathogen screening.
Original language | English (US) |
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Pages (from-to) | e71-76 |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
Volume | 43 |
Issue number | 8 |
DOIs | |
State | Published - Oct 15 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases