@inproceedings{0eb401b1cff84f85b0cd23480d21c75c,
title = "Micro characterization of Mg and Mg alloy for biodegradable orthopedic implants application",
abstract = "Magnesium as a candidate metallic biomaterial for biodegradable orthopedic implants was evaluated in-vitro in terms of degradation behavior, biocompatibility and mechanical property both in macro- and micro-scale. Micro structure of pure Mg and AZ61 after degradation in both simulated body fluid (SBF) and cell culture environment were analyzed. Different from AZ61, pure Mg degraded at a higher rate and attracted large amount of salt precipitation which formed a layer covering the surface. Much less pitting degradation and salt deposition were observed on both pure Mg and AZ61 in cell culture environment compared to in SBF. After culturing for 7 days, EAhy926 cells growing on AZ61 showed significant higher proliferation rate as of cells growing on pure Mg. Higher proliferation rates indicated that cells grew better on slow-degrading AZ61 than on fast-degrading pure Mg. Cells growing on AZ61 proliferated much better and assembled together to form a consistent tissue-like micro-structure, while cells spread and reached out on the surface of pure Mg, possibly due to low cell density and lack of cellular communication. The elastic modulus and tensile yield strength of magnesium are closer to those of natural bone than other commonly used metallic biomaterials. It was shown that Mg was biodegradable, biocompatible and had appropriate mechanical strength, thus Mg and its alloys showed great potential for deployment in a new generation of biodegradable orthopedic implants.",
keywords = "AZ61, Biocompatibility, Degradation behavior, EAhy926, Immersion test, Magnesium, Tensile property",
author = "Haibo Gong and Antonios Kontsos and Yoontae Kim and Lelkes, {Peter I.} and Qingwei Zhang and Donggang Yao and Kavan Hazeli and Zhou, {Jack G.}",
year = "2012",
doi = "10.1115/MSEC2012-7395",
language = "English (US)",
isbn = "9780791854990",
series = "ASME 2012 International Manufacturing Science and Engineering Conference Collocated with the 40th North American Manufacturing Research Conference and in Participation with the Int. Conf., MSEC 2012",
pages = "891--895",
booktitle = "ASME 2012 International Manufacturing Science and Engineering Conference Collocated with the 40th North American Manufacturing Research Conf. and in Participation with the Int. Conf., MSEC 2012",
note = "ASME 2012 International Manufacturing Science and Engineering Conference, MSEC 2012 Collocated with the 40th North American Manufacturing Research Conference and in Participation with the International Conference ; Conference date: 04-06-2012 Through 08-06-2012",
}