TY - JOUR
T1 - Mice and flies and monkeys too
T2 - Caloric restriction rejuvenates the aging immune system of non-human primates
AU - Nikolich-Žugich, Janko
AU - Messaoudi, Ilhem
N1 - Funding Information:
Supported in part by the USPHS awards AG20719, AG21384 and AG23664 (to J.N-Z.) and RR0163 (ONPRC Center Grant) from the National Institute on Aging and the National Institute for Research Resources, National Institutes of Health.
Funding Information:
These studies were supported by the US Public Health Service Awards AG21384 from the National Institute of Aging and RR0163 from NCRR. We wish to thank Ms J. Warner and M. Fisher for expert technical assistance; Dr F. Koegler and Ms L. Pranger, M. Martin and A. Hobbs for expert animal handling and schedule coordination; Drs M. Mori and B. Park for statistical analysis and Drs D. Ingram, G. Roth and J. Mattison for stimulating discussion.
PY - 2005/11
Y1 - 2005/11
N2 - Humanity has been obsessed with extending life span and reversing the aging process throughout recorded history and this quest most likely preceded the invention of the written word. The search for eternal youth has spurred holy wars and precipitated the discovery of the new world (the 'Fountain of youth'). It therefore comes as no surprise that an increasingly greater amount of research effort is dedicated to improve our understanding of the aging process and finding interventions to moderate its impact on health. Caloric restriction (CR) is the only intervention in biology that consistently extends maximal and median life span in a variety of short-lived species. Several theories to explain the mechanisms of action of CR have been put forth, including the possibility that CR acts by retarding immune senescence. The question remains, however, whether CR will have the same beneficial impact on human aging, and, if so, how long does CR need to last to produce beneficial effects. To address this question, several groups initiated long-term studies in Rhesus macaques (RM) in the 1980s. Here, we review published data describing the impact of CR on the aging immune system of mice and primates, and discuss our unpublished data that delineate similarities and differences in the effects of CR upon T cell aging and homeostasis between these two models.
AB - Humanity has been obsessed with extending life span and reversing the aging process throughout recorded history and this quest most likely preceded the invention of the written word. The search for eternal youth has spurred holy wars and precipitated the discovery of the new world (the 'Fountain of youth'). It therefore comes as no surprise that an increasingly greater amount of research effort is dedicated to improve our understanding of the aging process and finding interventions to moderate its impact on health. Caloric restriction (CR) is the only intervention in biology that consistently extends maximal and median life span in a variety of short-lived species. Several theories to explain the mechanisms of action of CR have been put forth, including the possibility that CR acts by retarding immune senescence. The question remains, however, whether CR will have the same beneficial impact on human aging, and, if so, how long does CR need to last to produce beneficial effects. To address this question, several groups initiated long-term studies in Rhesus macaques (RM) in the 1980s. Here, we review published data describing the impact of CR on the aging immune system of mice and primates, and discuss our unpublished data that delineate similarities and differences in the effects of CR upon T cell aging and homeostasis between these two models.
KW - Caloric restriction
KW - Non-human primate
KW - Rhesus macaques
UR - http://www.scopus.com/inward/record.url?scp=27544454697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27544454697&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2005.06.007
DO - 10.1016/j.exger.2005.06.007
M3 - Review article
C2 - 16087306
AN - SCOPUS:27544454697
SN - 0531-5565
VL - 40
SP - 884
EP - 893
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 11
ER -