MGST1, a new soldier of NRF2 in the battle against ferroptotic death

Matthew Dodson; Annadurai Anandhan; Donna D. Zhang

doi:10.1016/j.chembiol.2021.05.013

MGST1, a new soldier of NRF2 in the battle against ferroptotic death

Matthew Dodson, Annadurai Anandhan, Donna D. Zhang

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In this issue of Cell Chemical Biology, Kuang et al. (2021) identify microsomal glutathione-S-transferase 1 (MGST1) as an NRF2 target gene that suppresses ferroptosis in pancreatic cancer cells. Mechanistically, MGST1 binds ALOX5 during ferroptosis induction, inhibiting lipid peroxide production. Thus, MGST1 could represent a viable therapeutic target for treating pancreatic cancer.

Original language	English (US)
Pages (from-to)	741-742
Number of pages	2
Journal	Cell Chemical Biology
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.chembiol.2021.05.013
State	Published - Jun 17 2021

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2021.05.013

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title = "MGST1, a new soldier of NRF2 in the battle against ferroptotic death",

abstract = "In this issue of Cell Chemical Biology, Kuang et al. (2021) identify microsomal glutathione-S-transferase 1 (MGST1) as an NRF2 target gene that suppresses ferroptosis in pancreatic cancer cells. Mechanistically, MGST1 binds ALOX5 during ferroptosis induction, inhibiting lipid peroxide production. Thus, MGST1 could represent a viable therapeutic target for treating pancreatic cancer.",

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AU - Anandhan, Annadurai

AU - Zhang, Donna D.

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AB - In this issue of Cell Chemical Biology, Kuang et al. (2021) identify microsomal glutathione-S-transferase 1 (MGST1) as an NRF2 target gene that suppresses ferroptosis in pancreatic cancer cells. Mechanistically, MGST1 binds ALOX5 during ferroptosis induction, inhibiting lipid peroxide production. Thus, MGST1 could represent a viable therapeutic target for treating pancreatic cancer.

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MGST1, a new soldier of NRF2 in the battle against ferroptotic death

Abstract

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