Methyl diethyldithiocarbamate, a metabolite of disulfiram in man

John Cobby; Michael Mayersohn; Sathi Selliah

doi:10.1016/0024-3205(77)90259-4

Methyl diethyldithiocarbamate, a metabolite of disulfiram in man

John Cobby, Michael Mayersohn, Sathi Selliah

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Following the oral administration of disulfiram to alcoholic patient volunteers, methyl diethyldithiocarbamate (MeDDC) was noted in blood withdrawn between one and two hours after dosing. This is consistent with previous reports of MeDDC in mice and dogs. It is suggested that MeDDC is an intermediate in the formation of urinary sulfate.

Original language	English (US)
Pages (from-to)	937-941
Number of pages	5
Journal	Life Sciences
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(77)90259-4
State	Published - Oct 1 1977
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(77)90259-4

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title = "Methyl diethyldithiocarbamate, a metabolite of disulfiram in man",

abstract = "Following the oral administration of disulfiram to alcoholic patient volunteers, methyl diethyldithiocarbamate (MeDDC) was noted in blood withdrawn between one and two hours after dosing. This is consistent with previous reports of MeDDC in mice and dogs. It is suggested that MeDDC is an intermediate in the formation of urinary sulfate.",

author = "John Cobby and Michael Mayersohn and Sathi Selliah",

note = "Funding Information: Financial support was received from the Atkinson Charitable Foundation (Toronto) and from the Non-Medical Use of Drugs Directorate, Health and Welfare Canada (grant ~ 1212-5-206) .",

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AU - Mayersohn, Michael

AU - Selliah, Sathi

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PY - 1977/10/1

Y1 - 1977/10/1

N2 - Following the oral administration of disulfiram to alcoholic patient volunteers, methyl diethyldithiocarbamate (MeDDC) was noted in blood withdrawn between one and two hours after dosing. This is consistent with previous reports of MeDDC in mice and dogs. It is suggested that MeDDC is an intermediate in the formation of urinary sulfate.

AB - Following the oral administration of disulfiram to alcoholic patient volunteers, methyl diethyldithiocarbamate (MeDDC) was noted in blood withdrawn between one and two hours after dosing. This is consistent with previous reports of MeDDC in mice and dogs. It is suggested that MeDDC is an intermediate in the formation of urinary sulfate.

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Methyl diethyldithiocarbamate, a metabolite of disulfiram in man

Abstract

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