Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography

Paul S. Sheeran; Naomi Matsuura; Mark A. Borden; Ross Williams; Terry O. Matsunaga; Peter N. Burns; Paul A. Dayton

doi:10.1109/TUFFC.2016.2619685

Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography

Paul S. Sheeran, Naomi Matsuura, Mark A. Borden, Ross Williams, Terry O. Matsunaga, Peter N. Burns, Paul A. Dayton

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Continued advances in the field of ultrasound and ultrasound contrast agents have created new approaches to imaging and medical intervention. Phase-shift perfluorocarbon droplets, which can be vaporized by ultrasound energy to transition from the liquid to the vapor state, are one of the most highly researched alternatives to clinical ultrasound contrast agents (i.e., microbubbles). In this paper, part of a special issue on methods in biomedical ultrasonics, we survey current techniques to prepare ultrasound-activated nanoscale phase-shift perfluorocarbon droplets, including sonication, extrusion, homogenization, microfluidics, and microbubble condensation. We provide example protocols and discuss advantages and limitations of each approach. Finally, we discuss best practice in characterization of this class of contrast agents with respect to size distribution and ultrasound activation.

Original language	English (US)
Article number	7604095
Pages (from-to)	252-263
Number of pages	12
Journal	IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume	64
Issue number	1
DOIs	https://doi.org/10.1109/TUFFC.2016.2619685
State	Published - Jan 2017
Externally published	Yes

Keywords

High-intensity focused ultrasound
medical imaging
therapeutics
ultrasound contrast agents

ASJC Scopus subject areas

Instrumentation
Acoustics and Ultrasonics
Electrical and Electronic Engineering

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10.1109/TUFFC.2016.2619685

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Sheeran, P. S., Matsuura, N., Borden, M. A., Williams, R., Matsunaga, T. O., Burns, P. N., & Dayton, P. A. (2017). Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 64(1), 252-263. [7604095]. https://doi.org/10.1109/TUFFC.2016.2619685

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abstract = "Continued advances in the field of ultrasound and ultrasound contrast agents have created new approaches to imaging and medical intervention. Phase-shift perfluorocarbon droplets, which can be vaporized by ultrasound energy to transition from the liquid to the vapor state, are one of the most highly researched alternatives to clinical ultrasound contrast agents (i.e., microbubbles). In this paper, part of a special issue on methods in biomedical ultrasonics, we survey current techniques to prepare ultrasound-activated nanoscale phase-shift perfluorocarbon droplets, including sonication, extrusion, homogenization, microfluidics, and microbubble condensation. We provide example protocols and discuss advantages and limitations of each approach. Finally, we discuss best practice in characterization of this class of contrast agents with respect to size distribution and ultrasound activation.",

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author = "Sheeran, {Paul S.} and Naomi Matsuura and Borden, {Mark A.} and Ross Williams and Matsunaga, {Terry O.} and Burns, {Peter N.} and Dayton, {Paul A.}",

note = "Funding Information: This work was supported in part by the Canadian Institutes of Health Research under Grant MOP119346, in part by the Ontario Institute for Cancer Research, in part by the Ontario Research Fund-Research Excellence Program and the Early Researcher Award under Grant ER14-10-178, in part by the Prostate Cancer Canada Movember Foundation under Grant D2014-7, in part by the Fight Against Cancer Innovation Trust, in part by the Canadian Cancer Society under Grant 703909, in part by the NSERC Discovery Grants Program under Grant RGPIN-2015-05835, in part by the Focused Ultrasound Foundation, in part by the National Science Foundation under Grant DMR1122383 and Grant NIH R21EB01174, and in part by the Carolina Center for Cancer Nanotechnology Excellence. The work of P. S. Sheeran was supported by the Banting Postdoctoral Fellowship, Canadian Institutes of Health Research. Publisher Copyright: {\textcopyright} 1986-2012 IEEE.",

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Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography

Abstract

Keywords

ASJC Scopus subject areas

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