Metabolism of tyramine in the central nervous system of the moth Manduca sexta

Gerald D. Maxwell; Marcia M. Moore; John G. Hildebrand

doi:10.1016/0020-1790(80)90055-4

Metabolism of tyramine in the central nervous system of the moth Manduca sexta

Gerald D. Maxwell, Marcia M. Moore, John G. Hildebrand

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Three distinct metabolites of tyramine are produced by central nervous tissue of pharate-adult Manduca sexta incubated in vitro with [³H]-tyramine. The chemical identities of these metabolites have been sought by a combination of electrophoretic, chromatographic, hydrolytic and enzymic procedures. One of the compounds is N-acetyltyramine, and the others appear to be β-alanyltyramine and a sugar conjugate, possibly of N-acetyltyramine.

Original language	English (US)
Pages (from-to)	657-665
Number of pages	9
Journal	Insect Biochemistry
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/0020-1790(80)90055-4
State	Published - 1980
Externally published	Yes

Keywords

Manduca sexta
N-acetyltyramine
Tyramine
biogenic amines
monoamine metabolism
nervous system
β-alanyltyramine

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10.1016/0020-1790(80)90055-4

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@article{aa91e70c1e814be7b836d1bedc7ab341,

title = "Metabolism of tyramine in the central nervous system of the moth Manduca sexta",

abstract = "Three distinct metabolites of tyramine are produced by central nervous tissue of pharate-adult Manduca sexta incubated in vitro with [3H]-tyramine. The chemical identities of these metabolites have been sought by a combination of electrophoretic, chromatographic, hydrolytic and enzymic procedures. One of the compounds is N-acetyltyramine, and the others appear to be β-alanyltyramine and a sugar conjugate, possibly of N-acetyltyramine.",

keywords = "Manduca sexta, N-acetyltyramine, Tyramine, biogenic amines, monoamine metabolism, nervous system, β-alanyltyramine",

author = "Maxwell, {Gerald D.} and Moore, {Marcia M.} and Hildebrand, {John G.}",

note = "Funding Information: Acknowledgments--We are grateful to S. BLANK, V. ECKER, H. FERGUSON, J. GAGLIARDI, M. HILLS, J. THOMPSONa nd S. WILSONf or assistance. We thank Drs C. M. WILLIAMSa nd A. J. BAUMHOVERf or generously providing Manduca eggs, Dr. M. KENNEDYf or helpful discussions, and Dr. W. YON E. DOERINGf or providing laboratory facilities for M. M. M. to carry out chemical synthesis of N-acetyltyramine. This research has been supported",

year = "1980",

doi = "10.1016/0020-1790(80)90055-4",

language = "English (US)",

volume = "10",

pages = "657--665",

journal = "Insect Biochemistry",

issn = "0020-1790",

publisher = "Elsevier Ltd",

number = "6",

}

TY - JOUR

T1 - Metabolism of tyramine in the central nervous system of the moth Manduca sexta

AU - Maxwell, Gerald D.

AU - Moore, Marcia M.

AU - Hildebrand, John G.

N1 - Funding Information: Acknowledgments--We are grateful to S. BLANK, V. ECKER, H. FERGUSON, J. GAGLIARDI, M. HILLS, J. THOMPSONa nd S. WILSONf or assistance. We thank Drs C. M. WILLIAMSa nd A. J. BAUMHOVERf or generously providing Manduca eggs, Dr. M. KENNEDYf or helpful discussions, and Dr. W. YON E. DOERINGf or providing laboratory facilities for M. M. M. to carry out chemical synthesis of N-acetyltyramine. This research has been supported

PY - 1980

Y1 - 1980

N2 - Three distinct metabolites of tyramine are produced by central nervous tissue of pharate-adult Manduca sexta incubated in vitro with [3H]-tyramine. The chemical identities of these metabolites have been sought by a combination of electrophoretic, chromatographic, hydrolytic and enzymic procedures. One of the compounds is N-acetyltyramine, and the others appear to be β-alanyltyramine and a sugar conjugate, possibly of N-acetyltyramine.

AB - Three distinct metabolites of tyramine are produced by central nervous tissue of pharate-adult Manduca sexta incubated in vitro with [3H]-tyramine. The chemical identities of these metabolites have been sought by a combination of electrophoretic, chromatographic, hydrolytic and enzymic procedures. One of the compounds is N-acetyltyramine, and the others appear to be β-alanyltyramine and a sugar conjugate, possibly of N-acetyltyramine.

KW - Manduca sexta

KW - N-acetyltyramine

KW - Tyramine

KW - biogenic amines

KW - monoamine metabolism

KW - nervous system

KW - β-alanyltyramine

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U2 - 10.1016/0020-1790(80)90055-4

DO - 10.1016/0020-1790(80)90055-4

M3 - Article

AN - SCOPUS:0342940680

SN - 0020-1790

VL - 10

SP - 657

EP - 665

JO - Insect Biochemistry

JF - Insect Biochemistry

IS - 6

ER -

Metabolism of tyramine in the central nervous system of the moth Manduca sexta

Abstract

Keywords

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