Metabolism of Hexachlorophene in the Rabbit. Excretion, Tissue Distribution, and Characterization of the Urinary Glucuronide Conjugate

A. Jay Gandolfi; Donald R. Buhler

doi:10.1021/jf60209a001

Metabolism of Hexachlorophene in the Rabbit. Excretion, Tissue Distribution, and Characterization of the Urinary Glucuronide Conjugate

A. Jay Gandolfi
, Donald R. Buhler

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Rabbits were given intraperitoneal doses of 10 or 15 mg/kg [ ¹⁴C]hexachlorophene. About 48-52% of the administered radioactivity was excreted in the feces and 21-25% in the urine over a 3.5-4-day period. Unchanged hexachlorophene (HCP) was a major constituent of feces (78%) and urine (29%) of rabbits receiving a 15 mg/kg dose of [¹⁴C]HCP. The major urinary metabolite (56%), HCP glucuronide, was isolated and characterized.

Original language	English (US)
Pages (from-to)	21-25
Number of pages	5
Journal	Journal of agricultural and food chemistry
Volume	25
Issue number	1
DOIs	https://doi.org/10.1021/jf60209a001
State	Published - Jan 1 1977
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Agricultural and Biological Sciences

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abstract = "Rabbits were given intraperitoneal doses of 10 or 15 mg/kg [ 14C]hexachlorophene. About 48-52\% of the administered radioactivity was excreted in the feces and 21-25\% in the urine over a 3.5-4-day period. Unchanged hexachlorophene (HCP) was a major constituent of feces (78\%) and urine (29\%) of rabbits receiving a 15 mg/kg dose of [14C]HCP. The major urinary metabolite (56\%), HCP glucuronide, was isolated and characterized.",

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AU - Buhler, Donald R.

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Y1 - 1977/1/1

N2 - Rabbits were given intraperitoneal doses of 10 or 15 mg/kg [ 14C]hexachlorophene. About 48-52% of the administered radioactivity was excreted in the feces and 21-25% in the urine over a 3.5-4-day period. Unchanged hexachlorophene (HCP) was a major constituent of feces (78%) and urine (29%) of rabbits receiving a 15 mg/kg dose of [14C]HCP. The major urinary metabolite (56%), HCP glucuronide, was isolated and characterized.

AB - Rabbits were given intraperitoneal doses of 10 or 15 mg/kg [ 14C]hexachlorophene. About 48-52% of the administered radioactivity was excreted in the feces and 21-25% in the urine over a 3.5-4-day period. Unchanged hexachlorophene (HCP) was a major constituent of feces (78%) and urine (29%) of rabbits receiving a 15 mg/kg dose of [14C]HCP. The major urinary metabolite (56%), HCP glucuronide, was isolated and characterized.

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IS - 1

ER -

Metabolism of Hexachlorophene in the Rabbit. Excretion, Tissue Distribution, and Characterization of the Urinary Glucuronide Conjugate

Abstract

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