Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia

K. D. Gierke; P. E. Graves; D. Perrier; F. I. Marcus; M. Mayersohn; S. Goldman

Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia

K. D. Gierke, P. E. Graves, D. Perrier, F. I. Marcus, M. Mayersohn, S. Goldman

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study was to evaluate the metabolism and rate of elimination of digoxigenin bisdigitoxoside (bis) before and during chronic azotemia in dogs. Bis was eliminated primarily by nonrenal mechanisms. The half-life of bis was 18.5 hr, compared to 31.6 hr for digoxin, and was not significantly increased in azotemic dogs. The oral bioavailability of bis in azotemic dogs relative to an intravenous dose was approximately 46%.

Original language	English (US)
Pages (from-to)	448-451
Number of pages	4
Journal	Journal of Pharmacology and Experimental Therapeutics
Volume	212
Issue number	3
State	Published - 1980

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

Cite this

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title = "Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia",

abstract = "The purpose of this study was to evaluate the metabolism and rate of elimination of digoxigenin bisdigitoxoside (bis) before and during chronic azotemia in dogs. Bis was eliminated primarily by nonrenal mechanisms. The half-life of bis was 18.5 hr, compared to 31.6 hr for digoxin, and was not significantly increased in azotemic dogs. The oral bioavailability of bis in azotemic dogs relative to an intravenous dose was approximately 46%.",

author = "Gierke, {K. D.} and Graves, {P. E.} and D. Perrier and Marcus, {F. I.} and M. Mayersohn and S. Goldman",

year = "1980",

language = "English (US)",

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pages = "448--451",

journal = "Journal of Pharmacology and Experimental Therapeutics",

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T1 - Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia

AU - Gierke, K. D.

AU - Graves, P. E.

AU - Perrier, D.

AU - Marcus, F. I.

AU - Mayersohn, M.

AU - Goldman, S.

PY - 1980

Y1 - 1980

N2 - The purpose of this study was to evaluate the metabolism and rate of elimination of digoxigenin bisdigitoxoside (bis) before and during chronic azotemia in dogs. Bis was eliminated primarily by nonrenal mechanisms. The half-life of bis was 18.5 hr, compared to 31.6 hr for digoxin, and was not significantly increased in azotemic dogs. The oral bioavailability of bis in azotemic dogs relative to an intravenous dose was approximately 46%.

AB - The purpose of this study was to evaluate the metabolism and rate of elimination of digoxigenin bisdigitoxoside (bis) before and during chronic azotemia in dogs. Bis was eliminated primarily by nonrenal mechanisms. The half-life of bis was 18.5 hr, compared to 31.6 hr for digoxin, and was not significantly increased in azotemic dogs. The oral bioavailability of bis in azotemic dogs relative to an intravenous dose was approximately 46%.

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JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

IS - 3

ER -

Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia

Abstract

ASJC Scopus subject areas

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