Membrane NMR: a dyanmic research area

Michael F. Brown; Gerald D. Williams

doi:10.1016/0165-022X(85)90043-0

Membrane NMR: a dyanmic research area

Michael F. Brown, Gerald D. Williams

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

Recent NMR relaxation studies of lipid bilayers and biomembranes are explained and briefly discussed. The results of both ²H and ¹³C NMR investigations suggest that, in addition to rapid local fluctuations of the hydrocarbon chains, slower, more collective motions of the bilayer exist. When the influence of the latter is recognized and properly accounted for, the contribution from local motions can be used to estimate a value for the microviscosity of the bilayer which corresponds to that of a simple n-paraffinic liquid. In general, the dynamic behavior of lipid bilayers as studied by NMR appears quite similar to that of simpler liquid crystals.

Original language	English (US)
Pages (from-to)	71-81
Number of pages	11
Journal	Journal of Biochemical and Biophysical Methods
Volume	11
Issue number	2-3
DOIs	https://doi.org/10.1016/0165-022X(85)90043-0
State	Published - Aug 1985
Externally published	Yes

Keywords

NMR
lipid bilayers
liquid crystals
microviscosity
molecular dynamics

ASJC Scopus subject areas

Biophysics
Biochemistry

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10.1016/0165-022X(85)90043-0

Cite this

@article{6f754148cc8f44dfb9a4e01fa80d85f5,

title = "Membrane NMR: a dyanmic research area",

abstract = "Recent NMR relaxation studies of lipid bilayers and biomembranes are explained and briefly discussed. The results of both 2H and 13C NMR investigations suggest that, in addition to rapid local fluctuations of the hydrocarbon chains, slower, more collective motions of the bilayer exist. When the influence of the latter is recognized and properly accounted for, the contribution from local motions can be used to estimate a value for the microviscosity of the bilayer which corresponds to that of a simple n-paraffinic liquid. In general, the dynamic behavior of lipid bilayers as studied by NMR appears quite similar to that of simpler liquid crystals.",

keywords = "NMR, lipid bilayers, liquid crystals, microviscosity, molecular dynamics",

author = "Brown, {Michael F.} and Williams, {Gerald D.}",

note = "Funding Information: Many thanks are due to those friends and colleagues who have contributed to the work described and who have offered advice, criticism, and discussion. We are also grateful to Jack Cohen and John Nagle for their comments on the manuscript. Work supported by NIH Grant EY03754, Research Career Development Award EY00255 from the NIH, and by the Monsanto Company (M.F.B.).",

year = "1985",

month = aug,

doi = "10.1016/0165-022X(85)90043-0",

language = "English (US)",

volume = "11",

pages = "71--81",

journal = "Journal of Biochemical and Biophysical Methods",

issn = "0165-022X",

publisher = "Elsevier",

number = "2-3",

}

TY - JOUR

T1 - Membrane NMR

T2 - a dyanmic research area

AU - Brown, Michael F.

AU - Williams, Gerald D.

N1 - Funding Information: Many thanks are due to those friends and colleagues who have contributed to the work described and who have offered advice, criticism, and discussion. We are also grateful to Jack Cohen and John Nagle for their comments on the manuscript. Work supported by NIH Grant EY03754, Research Career Development Award EY00255 from the NIH, and by the Monsanto Company (M.F.B.).

PY - 1985/8

Y1 - 1985/8

N2 - Recent NMR relaxation studies of lipid bilayers and biomembranes are explained and briefly discussed. The results of both 2H and 13C NMR investigations suggest that, in addition to rapid local fluctuations of the hydrocarbon chains, slower, more collective motions of the bilayer exist. When the influence of the latter is recognized and properly accounted for, the contribution from local motions can be used to estimate a value for the microviscosity of the bilayer which corresponds to that of a simple n-paraffinic liquid. In general, the dynamic behavior of lipid bilayers as studied by NMR appears quite similar to that of simpler liquid crystals.

AB - Recent NMR relaxation studies of lipid bilayers and biomembranes are explained and briefly discussed. The results of both 2H and 13C NMR investigations suggest that, in addition to rapid local fluctuations of the hydrocarbon chains, slower, more collective motions of the bilayer exist. When the influence of the latter is recognized and properly accounted for, the contribution from local motions can be used to estimate a value for the microviscosity of the bilayer which corresponds to that of a simple n-paraffinic liquid. In general, the dynamic behavior of lipid bilayers as studied by NMR appears quite similar to that of simpler liquid crystals.

KW - NMR

KW - lipid bilayers

KW - liquid crystals

KW - microviscosity

KW - molecular dynamics

UR - http://www.scopus.com/inward/record.url?scp=0022107155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022107155&partnerID=8YFLogxK

U2 - 10.1016/0165-022X(85)90043-0

DO - 10.1016/0165-022X(85)90043-0

M3 - Short survey

C2 - 3897353

AN - SCOPUS:0022107155

SN - 0165-022X

VL - 11

SP - 71

EP - 81

JO - Journal of Biochemical and Biophysical Methods

JF - Journal of Biochemical and Biophysical Methods

IS - 2-3

ER -

Membrane NMR: a dyanmic research area

Abstract

Keywords

ASJC Scopus subject areas

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