Membrane domains and macromolecular transport in intestinal epithelial cells

M. R. Neutra, J. M. Wilson, R. A. Weltzin, J. P. Kraehenbuhl

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Epithelial cell plasma membranes are organized as biochemically and functionally distinct domains and subdomains. We have explored the composition and maintenance of specific membrane regions during endocytosis and transepithelial vesicular transport in specialized cells of the intestinal epithelium. A unique membrane glycoprotein has been identified in apical endocytic subdomains and endosomal tubules of absorptive cells in suckling rat ileum. This endocytic system is involved in sorting and transepithelial transport of peptide growth factors as well as delivery of milk macromolecules to lysosomes. In M cells of follicle-associated epithelium, we have shown that membrane-bound proteins are efficiently transported to a specialized subdomain of basolateral membrane. The apical membranes of these cells bear immunoglobulin bindings sites and transport monoclonal IgA antibodies to the basolateral side, where they may interact with cells of the mucosal immune system.

Original languageEnglish (US)
Pages (from-to)S10-S16
JournalAmerican Review of Respiratory Disease
Issue number6 II
StatePublished - 1988

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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