Melatonin induced increase in gamma-interferon production by murine splenocytes

Lucas Luis Colombo; Guan Jie Chen; Maria C. Lopez; Ronald Ross Watson

doi:10.1016/0165-2478(92)90035-M

Melatonin induced increase in gamma-interferon production by murine splenocytes

Lucas Luis Colombo, Guan Jie Chen, Maria C. Lopez, Ronald Ross Watson

Health Promotion Sciences

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Previously, we demonstrated that production of gamma-interferon (γ-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased γ-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).

Original language	English (US)
Pages (from-to)	123-126
Number of pages	4
Journal	Immunology Letters
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/0165-2478(92)90035-M
State	Published - Jul 1992

Keywords

Circadian rhythm
Melatonin
Pineal
γ-IFN

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0165-2478(92)90035-M

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title = "Melatonin induced increase in gamma-interferon production by murine splenocytes",

abstract = "Previously, we demonstrated that production of gamma-interferon (γ-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased γ-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).",

keywords = "Circadian rhythm, Melatonin, Pineal, γ-IFN",

author = "Colombo, {Lucas Luis} and Chen, {Guan Jie} and Lopez, {Maria C.} and Watson, {Ronald Ross}",

note = "Funding Information: The authors greatly appreciate the technical assistance of Kathleen Kunke running the samples, in the FACSCAN. Supported by NIH grants AA08037 and DA04827.",

year = "1992",

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doi = "10.1016/0165-2478(92)90035-M",

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pages = "123--126",

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T1 - Melatonin induced increase in gamma-interferon production by murine splenocytes

AU - Colombo, Lucas Luis

AU - Chen, Guan Jie

AU - Lopez, Maria C.

AU - Watson, Ronald Ross

N1 - Funding Information: The authors greatly appreciate the technical assistance of Kathleen Kunke running the samples, in the FACSCAN. Supported by NIH grants AA08037 and DA04827.

PY - 1992/7

Y1 - 1992/7

N2 - Previously, we demonstrated that production of gamma-interferon (γ-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased γ-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).

AB - Previously, we demonstrated that production of gamma-interferon (γ-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased γ-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).

KW - Circadian rhythm

KW - Melatonin

KW - Pineal

KW - γ-IFN

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SN - 0165-2478

VL - 33

SP - 123

EP - 126

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -

Melatonin induced increase in gamma-interferon production by murine splenocytes

Abstract

Keywords

ASJC Scopus subject areas

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