Melatonin induced increase in gamma-interferon production by murine splenocytes

Lucas Luis Colombo, Guan Jie Chen, Maria C. Lopez, Ronald Ross Watson

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Previously, we demonstrated that production of gamma-interferon (γ-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased γ-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalImmunology Letters
Issue number2
StatePublished - Jul 1992


  • Circadian rhythm
  • Melatonin
  • Pineal
  • γ-IFN

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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