Melanomagenic gene alterations viewed from a redox perspective: Molecular mechanisms and therapeutic opportunities

Georg T Wondrak

doi:10.1007/978-94-017-9421-3_13

Melanomagenic gene alterations viewed from a redox perspective: Molecular mechanisms and therapeutic opportunities

Georg T Wondrak

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The causative involvement of altered redox homeostasis and reactive oxygen species (ROS)-dependent signaling in the control of survival, proliferation, and invasiveness of cancer cells has recently emerged. A large body of experimental and epidemiological research has substantiated the causative involvement of specific genetic alterations in melanomagenesis. Strikingly, some of the proteins encoded by specific genes underlying melanomagenesis (CDKN2A, MC1R, MITF, KIT, NRAS, BRAF, AKT3, PTEN, RAC1, MAP3K5, KEAP1, MYC) assume mechanistic roles in the control of cellular redox signaling and oxidative stress, thereby fulfilling molecular functions relevant to suppression or promotion of tumorigenesis that reach beyond their canonical activities, a significant yet underappreciated phenomenon that may open avenues towards novel redox-directed chemotherapeutic interventions as discussed in this chapter.

Original language	English (US)
Title of host publication	Stress Response Pathways in Cancer
Subtitle of host publication	From Molecular Targets to Novel Therapeutics
Publisher	Springer Netherlands
Pages	285-309
Number of pages	25
ISBN (Electronic)	9789401794213
ISBN (Print)	9789401794206
DOIs	https://doi.org/10.1007/978-94-017-9421-3_13
State	Published - Jan 1 2015

Keywords

Chemotherapy
Melanocyte
Melanoma
Melanomagenesis
Synthetic lethality
Targeted therapeutics

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-94-017-9421-3_13

Cite this

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abstract = "The causative involvement of altered redox homeostasis and reactive oxygen species (ROS)-dependent signaling in the control of survival, proliferation, and invasiveness of cancer cells has recently emerged. A large body of experimental and epidemiological research has substantiated the causative involvement of specific genetic alterations in melanomagenesis. Strikingly, some of the proteins encoded by specific genes underlying melanomagenesis (CDKN2A, MC1R, MITF, KIT, NRAS, BRAF, AKT3, PTEN, RAC1, MAP3K5, KEAP1, MYC) assume mechanistic roles in the control of cellular redox signaling and oxidative stress, thereby fulfilling molecular functions relevant to suppression or promotion of tumorigenesis that reach beyond their canonical activities, a significant yet underappreciated phenomenon that may open avenues towards novel redox-directed chemotherapeutic interventions as discussed in this chapter.",

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KW - Targeted therapeutics

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Melanomagenic gene alterations viewed from a redox perspective: Molecular mechanisms and therapeutic opportunities

Abstract

Keywords

ASJC Scopus subject areas

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