TY - JOUR
T1 - Melanocytes, melanocyte stem cells, and melanoma stem cells
AU - Lang, Deborah
AU - Mascarenhas, Joseph B.
AU - Shea, Christopher R.
N1 - Funding Information:
The authors are grateful to our colleagues whose works we cite here, and we apologize for the omission of other relevant works owing to space restrictions. Supported by The University of Chicago Department of Medicine/Section of Dermatology, University of Chicago Cancer Center Pilot program ( P30 CA014599 ), Friends of Dermatology-University of Chicago, the American Cancer Society ( RSG CSM 121505 ), and the National Institutes of Health ( R01CA130202 ).
PY - 2013/3
Y1 - 2013/3
N2 - Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role in a lethal form of cancer. These 2 cell types share several features and can be studied by similar methods. Aspects held in common by both melanocyte stem cells and melanoma stem cells include their expression of shared biochemical markers, a system of similar molecular signals necessary for their maintenance, and a requirement for an ideal niche microenvironment for providing these factors. This review provides a perspective of both these cell types and discusses potential models of stem cell growth and propagation. Recent findings provide a strong foundation for the development of new therapeutics directed at isolating and manipulating melanocyte stem cells for tissue engineering or at targeting and eradicating melanoma specifically, while sparing nontumor cells.
AB - Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role in a lethal form of cancer. These 2 cell types share several features and can be studied by similar methods. Aspects held in common by both melanocyte stem cells and melanoma stem cells include their expression of shared biochemical markers, a system of similar molecular signals necessary for their maintenance, and a requirement for an ideal niche microenvironment for providing these factors. This review provides a perspective of both these cell types and discusses potential models of stem cell growth and propagation. Recent findings provide a strong foundation for the development of new therapeutics directed at isolating and manipulating melanocyte stem cells for tissue engineering or at targeting and eradicating melanoma specifically, while sparing nontumor cells.
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U2 - 10.1016/j.clindermatol.2012.08.014
DO - 10.1016/j.clindermatol.2012.08.014
M3 - Article
C2 - 23438380
AN - SCOPUS:84874239795
SN - 0738-081X
VL - 31
SP - 166
EP - 178
JO - Clinics in Dermatology
JF - Clinics in Dermatology
IS - 2
ER -