Melanin concentrating hormone (MCH): The message sequence

Ana Maria de L. Castrucci; Michal Lebl; Victor J. Hruby; Terry O. Matsunaga; Mac E. Hadley

doi:10.1016/0024-3205(89)90501-8

Melanin concentrating hormone (MCH): The message sequence

Ana Maria de L. Castrucci, Michal Lebl, Victor J. Hruby, Terry O. Matsunaga, Mac E. Hadley

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melanocytes. We have synthesized a number of MCH analogues to determine the essential features of the primary structure necessary to stimulate either melanosome aggregation or dispersion in fish or tetrapod melanocytes, respectively. An analysis of the potencies and actions of these analogues on vertebrate melanocytes is provided and demonstrates that the two activities have different structural requirements.

Original language	English (US)
Pages (from-to)	1141-1148
Number of pages	8
Journal	Life Sciences
Volume	45
Issue number	13
DOIs	https://doi.org/10.1016/0024-3205(89)90501-8
State	Published - 1989

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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abstract = "Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melanocytes. We have synthesized a number of MCH analogues to determine the essential features of the primary structure necessary to stimulate either melanosome aggregation or dispersion in fish or tetrapod melanocytes, respectively. An analysis of the potencies and actions of these analogues on vertebrate melanocytes is provided and demonstrates that the two activities have different structural requirements.",

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T1 - Melanin concentrating hormone (MCH)

T2 - The message sequence

AU - Castrucci, Ana Maria de L.

AU - Lebl, Michal

AU - Hruby, Victor J.

AU - Matsunaga, Terry O.

AU - Hadley, Mac E.

PY - 1989

Y1 - 1989

N2 - Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melanocytes. We have synthesized a number of MCH analogues to determine the essential features of the primary structure necessary to stimulate either melanosome aggregation or dispersion in fish or tetrapod melanocytes, respectively. An analysis of the potencies and actions of these analogues on vertebrate melanocytes is provided and demonstrates that the two activities have different structural requirements.

AB - Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melanocytes. We have synthesized a number of MCH analogues to determine the essential features of the primary structure necessary to stimulate either melanosome aggregation or dispersion in fish or tetrapod melanocytes, respectively. An analysis of the potencies and actions of these analogues on vertebrate melanocytes is provided and demonstrates that the two activities have different structural requirements.

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Melanin concentrating hormone (MCH): The message sequence

Abstract

ASJC Scopus subject areas

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