TY - JOUR
T1 - Mechanosensing can result from adhesion molecule dynamics
AU - Krzyszczyk, Paulina
AU - Wolgemuth, Charles W.
N1 - Funding Information:
This work was supported by National Institutes of Health grant No. NIH U54 CA143868.
PY - 2011/11/16
Y1 - 2011/11/16
N2 - When plated onto a substrate, cells spread. Many cell types, including smooth muscle cells and fibroblasts, spread more effectively on stiffer substrates, and a simple empirical relationship has been determined that relates a cell's spread area to the substrate stiffness. In addition, some crawling cells when plated onto a stiff substrate will not migrate onto soft substrate, a process called "durotaxis". Here we show that the resistive force predicted previously for dynamic adhesion molecules can account for both of these mechanosensory effects.
AB - When plated onto a substrate, cells spread. Many cell types, including smooth muscle cells and fibroblasts, spread more effectively on stiffer substrates, and a simple empirical relationship has been determined that relates a cell's spread area to the substrate stiffness. In addition, some crawling cells when plated onto a stiff substrate will not migrate onto soft substrate, a process called "durotaxis". Here we show that the resistive force predicted previously for dynamic adhesion molecules can account for both of these mechanosensory effects.
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U2 - 10.1016/j.bpj.2011.10.003
DO - 10.1016/j.bpj.2011.10.003
M3 - Article
C2 - 22098759
AN - SCOPUS:81255164846
SN - 0006-3495
VL - 101
SP - L53-L55
JO - Biophysical Journal
JF - Biophysical Journal
IS - 10
ER -