Mechanobiology of the optic nerve head in primary open-angle glaucoma

Jr Jiun Liou; Jason E. Shoemaker; Jonathan P. Vande Geest

doi:10.1016/B978-0-12-817931-4.00003-0

Mechanobiology of the optic nerve head in primary open-angle glaucoma

Jr Jiun Liou, Jason E. Shoemaker, Jonathan P. Vande Geest

Aerospace and Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Primary open-angle glaucoma is a neurodegenerative disease that affects 60 million people globally; however, the specific mechanisms that govern the initiation and progression of the disease are currently unclear. In this chapter, we describe the structure and function of the optic nerve head, review how mechanical stimuli and mechanical properties affect the development of the disease, and provide a discussion of future directions.

Original language	English (US)
Title of host publication	Mechanobiology
Subtitle of host publication	From Molecular Sensing to Disease
Publisher	Elsevier
Pages	47-64
Number of pages	18
ISBN (Electronic)	9780128179314
DOIs	https://doi.org/10.1016/B978-0-12-817931-4.00003-0
State	Published - Jan 1 2019

Keywords

Biomechanics
Glaucoma
Intraocular pressure
Lamina cribrosa
Optic nerve head

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-817931-4.00003-0

Cite this

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abstract = "Primary open-angle glaucoma is a neurodegenerative disease that affects 60 million people globally; however, the specific mechanisms that govern the initiation and progression of the disease are currently unclear. In this chapter, we describe the structure and function of the optic nerve head, review how mechanical stimuli and mechanical properties affect the development of the disease, and provide a discussion of future directions.",

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AB - Primary open-angle glaucoma is a neurodegenerative disease that affects 60 million people globally; however, the specific mechanisms that govern the initiation and progression of the disease are currently unclear. In this chapter, we describe the structure and function of the optic nerve head, review how mechanical stimuli and mechanical properties affect the development of the disease, and provide a discussion of future directions.

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KW - Intraocular pressure

KW - Lamina cribrosa

KW - Optic nerve head

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ER -

Mechanobiology of the optic nerve head in primary open-angle glaucoma

Abstract

Keywords

ASJC Scopus subject areas

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