Mechanobiology of the optic nerve head in primary open-angle glaucoma

Jr Jiun Liou, Jason E. Shoemaker, Jonathan P. Vande Geest

Research output: Chapter in Book/Report/Conference proceedingChapter


Primary open-angle glaucoma is a neurodegenerative disease that affects 60 million people globally; however, the specific mechanisms that govern the initiation and progression of the disease are currently unclear. In this chapter, we describe the structure and function of the optic nerve head, review how mechanical stimuli and mechanical properties affect the development of the disease, and provide a discussion of future directions.

Original languageEnglish (US)
Title of host publicationMechanobiology
Subtitle of host publicationFrom Molecular Sensing to Disease
Number of pages18
ISBN (Electronic)9780128179314
StatePublished - Jan 1 2019


  • Biomechanics
  • Glaucoma
  • Intraocular pressure
  • Lamina cribrosa
  • Optic nerve head

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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