Mechanisms underlying thrombocytopenia in the neonatal intensive care unit

M. C. Sola; L. M. Rimsza

doi:10.1111/j.1651-2227.2002.tb02907.x

Mechanisms underlying thrombocytopenia in the neonatal intensive care unit

M. C. Sola, L. M. Rimsza

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Thrombocytopenia is one of the most common hematological problems among neonates in the neonatal intensive care unit (NICU), but in the majority of cases the kinetic mechanism responsible is unclear. This review focuses on both traditional and innovative methods used to evaluate the mechanisms responsible for thrombocytopenia in neonates, and analyzes the data generated from those methods. Conclusion: Results of studies using new methods for evaluating thrombocytopenia, coupled with recent descriptions of marrow megakaryocyte mass, suggest that decreased platelet production complicates most cases of thrombocytopenia among neonates in the NICU.

Original language	English (US)
Pages (from-to)	66-73
Number of pages	8
Journal	Acta Paediatrica, International Journal of Paediatrics, Supplement
Volume	91
Issue number	438
DOIs	https://doi.org/10.1111/j.1651-2227.2002.tb02907.x
State	Published - 2002
Externally published	Yes

Keywords

Bone marrow
Megakaryocyte progenitors
Megakaryocytes
Neonatal thrombocytopenia
Platelet kinetics

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1111/j.1651-2227.2002.tb02907.x

Cite this

@article{4a10b2c34baa429cb09d632edfbc9068,

title = "Mechanisms underlying thrombocytopenia in the neonatal intensive care unit",

abstract = "Thrombocytopenia is one of the most common hematological problems among neonates in the neonatal intensive care unit (NICU), but in the majority of cases the kinetic mechanism responsible is unclear. This review focuses on both traditional and innovative methods used to evaluate the mechanisms responsible for thrombocytopenia in neonates, and analyzes the data generated from those methods. Conclusion: Results of studies using new methods for evaluating thrombocytopenia, coupled with recent descriptions of marrow megakaryocyte mass, suggest that decreased platelet production complicates most cases of thrombocytopenia among neonates in the NICU.",

keywords = "Bone marrow, Megakaryocyte progenitors, Megakaryocytes, Neonatal thrombocytopenia, Platelet kinetics",

author = "Sola, {M. C.} and Rimsza, {L. M.}",

year = "2002",

doi = "10.1111/j.1651-2227.2002.tb02907.x",

language = "English (US)",

volume = "91",

pages = "66--73",

journal = "Acta Paediatrica, International Journal of Paediatrics, Supplement",

issn = "0803-5326",

publisher = "Taylor and Francis Ltd.",

number = "438",

}

TY - JOUR

T1 - Mechanisms underlying thrombocytopenia in the neonatal intensive care unit

AU - Sola, M. C.

AU - Rimsza, L. M.

PY - 2002

Y1 - 2002

N2 - Thrombocytopenia is one of the most common hematological problems among neonates in the neonatal intensive care unit (NICU), but in the majority of cases the kinetic mechanism responsible is unclear. This review focuses on both traditional and innovative methods used to evaluate the mechanisms responsible for thrombocytopenia in neonates, and analyzes the data generated from those methods. Conclusion: Results of studies using new methods for evaluating thrombocytopenia, coupled with recent descriptions of marrow megakaryocyte mass, suggest that decreased platelet production complicates most cases of thrombocytopenia among neonates in the NICU.

AB - Thrombocytopenia is one of the most common hematological problems among neonates in the neonatal intensive care unit (NICU), but in the majority of cases the kinetic mechanism responsible is unclear. This review focuses on both traditional and innovative methods used to evaluate the mechanisms responsible for thrombocytopenia in neonates, and analyzes the data generated from those methods. Conclusion: Results of studies using new methods for evaluating thrombocytopenia, coupled with recent descriptions of marrow megakaryocyte mass, suggest that decreased platelet production complicates most cases of thrombocytopenia among neonates in the NICU.

KW - Bone marrow

KW - Megakaryocyte progenitors

KW - Megakaryocytes

KW - Neonatal thrombocytopenia

KW - Platelet kinetics

UR - http://www.scopus.com/inward/record.url?scp=0036431005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036431005&partnerID=8YFLogxK

U2 - 10.1111/j.1651-2227.2002.tb02907.x

DO - 10.1111/j.1651-2227.2002.tb02907.x

M3 - Article

C2 - 12477266

AN - SCOPUS:0036431005

SN - 0803-5326

VL - 91

SP - 66

EP - 73

JO - Acta Paediatrica, International Journal of Paediatrics, Supplement

JF - Acta Paediatrica, International Journal of Paediatrics, Supplement

IS - 438

ER -

Mechanisms underlying thrombocytopenia in the neonatal intensive care unit

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this