Mechanisms of viral clearance in perforin-deficient mice

M. T. Lin, D. R. Hinton, S. A. Stohlman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The roles of CD4+ T cells, IFN-γ and TNF-α in viral clearance from the central nervous system (CNS) were examined in perforin gene deficient (PKO) mice. Depletion of CD4+ T cells from the PKO mice resulted in a significant 1 log10 PFU/gm increase in viral titer over control-treated PKO mice. PKO mice treated with anti-IFN-γ mAb also had a significant 1 log10 increase in infectious virus whereas inhibition of TNF-α did not alter viral clearance or clinical disease in the PKO mice. These data suggest, in addition to perforin-mediated cytolysis, CD4+ T cells and IFN-γ, but not TNF-α could contribute to JHMV clearance from the CNS.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalAdvances in experimental medicine and biology
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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