TY - JOUR
T1 - Mechanisms of viral clearance in perforin-deficient mice
AU - Lin, M. T.
AU - Hinton, D. R.
AU - Stohlman, S. A.
PY - 1998
Y1 - 1998
N2 - The roles of CD4+ T cells, IFN-γ and TNF-α in viral clearance from the central nervous system (CNS) were examined in perforin gene deficient (PKO) mice. Depletion of CD4+ T cells from the PKO mice resulted in a significant 1 log10 PFU/gm increase in viral titer over control-treated PKO mice. PKO mice treated with anti-IFN-γ mAb also had a significant 1 log10 increase in infectious virus whereas inhibition of TNF-α did not alter viral clearance or clinical disease in the PKO mice. These data suggest, in addition to perforin-mediated cytolysis, CD4+ T cells and IFN-γ, but not TNF-α could contribute to JHMV clearance from the CNS.
AB - The roles of CD4+ T cells, IFN-γ and TNF-α in viral clearance from the central nervous system (CNS) were examined in perforin gene deficient (PKO) mice. Depletion of CD4+ T cells from the PKO mice resulted in a significant 1 log10 PFU/gm increase in viral titer over control-treated PKO mice. PKO mice treated with anti-IFN-γ mAb also had a significant 1 log10 increase in infectious virus whereas inhibition of TNF-α did not alter viral clearance or clinical disease in the PKO mice. These data suggest, in addition to perforin-mediated cytolysis, CD4+ T cells and IFN-γ, but not TNF-α could contribute to JHMV clearance from the CNS.
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U2 - 10.1007/978-1-4615-5331-1_54
DO - 10.1007/978-1-4615-5331-1_54
M3 - Article
C2 - 9782311
AN - SCOPUS:0031721557
SN - 0065-2598
VL - 440
SP - 431
EP - 436
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -