Mechanisms of ischemic brain damage

Kristian P. Doyle, Roger P. Simon, Mary P. Stenzel-Poore

Research output: Contribution to journalArticlepeer-review

704 Scopus citations


In the United States stroke is the third leading cause of death and the leading cause of disability. Brain injury following stroke results from the complex interplay of multiple pathways including excitotoxicity, acidotoxicity, ionic imbalance, peri-infarct depolarization, oxidative and nitrative stress, inflammation and apoptosis. There are very few treatments for stroke and the development of new treatments requires a comprehensive understanding of the diverse mechanisms of ischemic brain damage that are responsible for neuronal death. Here, we discuss the underlying pathophysiology of this devastating disease and reveal the intertwined pathways that are the target of therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)310-318
Number of pages9
Issue number3
StatePublished - Sep 2008


  • Inflammation
  • Stroke
  • acidotoxicity
  • apoptosis
  • combinatorial therapy
  • excitotoxicity
  • ischemia

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience


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