Mechanisms of cocaine cardiotoxicity

David Solkoff, Ronald R. Watson

Research output: Chapter in Book/Report/Conference proceedingChapter


Cocaine abuse induces coronary vasospasm [1-5], myocardial infarction [6-8], hypertension [9,10], stroke [7,11], and fatal cardiac rhythm disorders, including ventricular fibrillation [12-15]. Chronic cocaine abuse has also been shown to cause dilated cardiomyopathy [16,17], and left ventricular hypertrophy in normotensive cocaine users [18-20]. It is only since modern electrocardiographic techniques have come into widespread use that the effect of cocaine on cardiac rhythm has been effectively studied. These techniques were the first to demonstrate that cocaine produced severe intractable ventricular arrhythmias that resulted in death during routine nasal surgery [21].

Original languageEnglish (US)
Title of host publicationAlcohol and Heart Disease
PublisherCRC Press
Number of pages7
ISBN (Electronic)9780203218853
ISBN (Print)9780415273473
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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