TY - JOUR
T1 - Mechanisms for chromosome and plasmid segregation
AU - Ghosh, Santanu Kumar
AU - Hajra, Sujata
AU - Paek, Andrew
AU - Jayaram, Makkuni
PY - 2006
Y1 - 2006
N2 - The fundamental problems in duplicating and transmitting genetic information posed by the geometric and topological features of DNA, combined with its large size, are qualitatively similar for prokaryotic and eukaryotic chromosomes. The evolutionary solutions to these problems reveal common themes. However, depending on differences in their organization, ploidy, and copy number, chromosomes and plasmids display distinct segregation strategies as well. In bacteria, chromosome duplication, likely mediated by a stationary replication factory, is accompanied by rapid, directed migration of the daughter duplexes with assistance from DNA-compacting and perhaps translocating proteins. The segregation of unit-copy or low-copy bacterial plasmids is also regulated spatially and temporally by their respective partitioning systems. Eukaryotic chromosomes utilize variations of a basic pairing and unpairing mechanism for faithful segregation during mitosis and meiosis. Rather surprisingly, the yeast plasmid 2-micron circle also resorts to a similar scheme for equal partitioning during mitosis.
AB - The fundamental problems in duplicating and transmitting genetic information posed by the geometric and topological features of DNA, combined with its large size, are qualitatively similar for prokaryotic and eukaryotic chromosomes. The evolutionary solutions to these problems reveal common themes. However, depending on differences in their organization, ploidy, and copy number, chromosomes and plasmids display distinct segregation strategies as well. In bacteria, chromosome duplication, likely mediated by a stationary replication factory, is accompanied by rapid, directed migration of the daughter duplexes with assistance from DNA-compacting and perhaps translocating proteins. The segregation of unit-copy or low-copy bacterial plasmids is also regulated spatially and temporally by their respective partitioning systems. Eukaryotic chromosomes utilize variations of a basic pairing and unpairing mechanism for faithful segregation during mitosis and meiosis. Rather surprisingly, the yeast plasmid 2-micron circle also resorts to a similar scheme for equal partitioning during mitosis.
KW - Cohesion
KW - Condensing
KW - Genome partitioning
KW - Rep proteins
KW - STB
KW - par loci
UR - http://www.scopus.com/inward/record.url?scp=33746363186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746363186&partnerID=8YFLogxK
U2 - 10.1146/annurev.biochem.75.101304.124037
DO - 10.1146/annurev.biochem.75.101304.124037
M3 - Review article
C2 - 16756491
AN - SCOPUS:33746363186
SN - 0066-4154
VL - 75
SP - 211
EP - 241
JO - Annual Review of Biochemistry
JF - Annual Review of Biochemistry
ER -