Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH

Katrina M. Miranda; Andrew S. Dutton; Lisa A. Ridnour; Christian A. Foreman; Eleonora Ford; Nazareno Paolocci; Tatsuo Katori; Carlo G. Tocchetti; Daniele Mancardi; Douglas D. Thomas; Michael G. Espey; K. N. Houk; Jon M. Fukuto; David A. Wink

doi:10.1021/ja045480z

Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH

Katrina M. Miranda, Andrew S. Dutton, Lisa A. Ridnour, Christian A. Foreman, Eleonora Ford, Nazareno Paolocci, Tatsuo Katori, Carlo G. Tocchetti, Daniele Mancardi, Douglas D. Thomas, Michael G. Espey, K. N. Houk, Jon M. Fukuto, David A. Wink

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98 Scopus citations

Abstract

The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.

Original language	English (US)
Pages (from-to)	722-731
Number of pages	10
Journal	Journal of the American Chemical Society
Volume	127
Issue number	2
DOIs	https://doi.org/10.1021/ja045480z
State	Published - Jan 19 2005

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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Miranda, K. M., Dutton, A. S., Ridnour, L. A., Foreman, C. A., Ford, E., Paolocci, N., Katori, T., Tocchetti, C. G., Mancardi, D., Thomas, D. D., Espey, M. G., Houk, K. N., Fukuto, J. M., & Wink, D. A. (2005). Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH. Journal of the American Chemical Society, 127(2), 722-731. https://doi.org/10.1021/ja045480z

Miranda, KM, Dutton, AS, Ridnour, LA, Foreman, CA, Ford, E, Paolocci, N, Katori, T, Tocchetti, CG, Mancardi, D, Thomas, DD, Espey, MG, Houk, KN, Fukuto, JM & Wink, DA 2005, 'Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH', Journal of the American Chemical Society, vol. 127, no. 2, pp. 722-731. https://doi.org/10.1021/ja045480z

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AU - Ford, Eleonora

AU - Paolocci, Nazareno

AU - Katori, Tatsuo

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AU - Mancardi, Daniele

AU - Thomas, Douglas D.

AU - Espey, Michael G.

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AU - Fukuto, Jon M.

AU - Wink, David A.

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Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH

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ASJC Scopus subject areas

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