Mechanism of action of retinyl compounds on wound healing I: Structural relationship of retinyl compounds and wound healing

K. H. Lee; Theodore G. Tong

doi:10.1002/jps.2600590630

Mechanism of action of retinyl compounds on wound healing I: Structural relationship of retinyl compounds and wound healing

K. H. Lee, Theodore G. Tong

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Retinol, retinyl acetate, and retinoic acid promote wound healing. Retinoic acid is most active. Beta‐carotene is active, while lycopene is inactive; β‐ionone is active and α‐ionone is inactive. For full activity, the compound should contain a β‐ionone ring, a conjugated double‐bond side chain, and a terminal carboxylic acid side chain.

Original language	English (US)
Pages (from-to)	851-854
Number of pages	4
Journal	Journal of pharmaceutical sciences
Volume	59
Issue number	6
DOIs	https://doi.org/10.1002/jps.2600590630
State	Published - Jun 1970
Externally published	Yes

Keywords

GLC—separation
NMR spectroscopy—identity
Retinyl compounds, activity—structural relationship
Wound healing—retinyl compound effect

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600590630

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title = "Mechanism of action of retinyl compounds on wound healing I: Structural relationship of retinyl compounds and wound healing",

abstract = "Retinol, retinyl acetate, and retinoic acid promote wound healing. Retinoic acid is most active. Beta‐carotene is active, while lycopene is inactive; β‐ionone is active and α‐ionone is inactive. For full activity, the compound should contain a β‐ionone ring, a conjugated double‐bond side chain, and a terminal carboxylic acid side chain.",

keywords = "GLC—separation, NMR spectroscopy—identity, Retinyl compounds, activity—structural relationship, Wound healing—retinyl compound effect",

author = "Lee, {K. H.} and Tong, {Theodore G.}",

year = "1970",

month = jun,

doi = "10.1002/jps.2600590630",

language = "English (US)",

volume = "59",

pages = "851--854",

journal = "Journal of pharmaceutical sciences",

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T1 - Mechanism of action of retinyl compounds on wound healing I

T2 - Structural relationship of retinyl compounds and wound healing

AU - Lee, K. H.

AU - Tong, Theodore G.

PY - 1970/6

Y1 - 1970/6

N2 - Retinol, retinyl acetate, and retinoic acid promote wound healing. Retinoic acid is most active. Beta‐carotene is active, while lycopene is inactive; β‐ionone is active and α‐ionone is inactive. For full activity, the compound should contain a β‐ionone ring, a conjugated double‐bond side chain, and a terminal carboxylic acid side chain.

AB - Retinol, retinyl acetate, and retinoic acid promote wound healing. Retinoic acid is most active. Beta‐carotene is active, while lycopene is inactive; β‐ionone is active and α‐ionone is inactive. For full activity, the compound should contain a β‐ionone ring, a conjugated double‐bond side chain, and a terminal carboxylic acid side chain.

KW - GLC—separation

KW - NMR spectroscopy—identity

KW - Retinyl compounds, activity—structural relationship

KW - Wound healing—retinyl compound effect

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DO - 10.1002/jps.2600590630

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JO - Journal of pharmaceutical sciences

JF - Journal of pharmaceutical sciences

IS - 6

ER -

Mechanism of action of retinyl compounds on wound healing I: Structural relationship of retinyl compounds and wound healing

Abstract

Keywords

ASJC Scopus subject areas

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