Mechanism-based isolation and structures of some anticancer active natural products

A. A. Leslie Gunatilaka; David G.I. Kingston; Randall K. Johnson

doi:10.1351/pac199466102219

Mechanism-based isolation and structures of some anticancer active natural products

A. A. Leslie Gunatilaka, David G.I. Kingston, Randall K. Johnson

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Application of a mechanism-based anticancer bioassay employing DNA repair-or recombination-deficient mutants of the yeast Saccharomyces cerevisiae for screening and subsequent bioassay-guided fractionation of bioactive higher plant and bryophyte extracts led to the isolation of a variety of natural products with potential anticancer activity. Presented herein are interesting structural features of some representative examples of natural products active in our mechanism-based bioassay and cytotoxicity assays along with structure-activity relationships of synthetic analogs of some of them.

Original language	English (US)
Pages (from-to)	2219-2222
Number of pages	4
Journal	Pure and Applied Chemistry
Volume	66
Issue number	10-11
DOIs	https://doi.org/10.1351/pac199466102219
State	Published - Jan 1 1994
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1351/pac199466102219

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@article{d487210eba404294a0b4488eecb93d56,

title = "Mechanism-based isolation and structures of some anticancer active natural products",

abstract = "Application of a mechanism-based anticancer bioassay employing DNA repair-or recombination-deficient mutants of the yeast Saccharomyces cerevisiae for screening and subsequent bioassay-guided fractionation of bioactive higher plant and bryophyte extracts led to the isolation of a variety of natural products with potential anticancer activity. Presented herein are interesting structural features of some representative examples of natural products active in our mechanism-based bioassay and cytotoxicity assays along with structure-activity relationships of synthetic analogs of some of them.",

author = "\{Leslie Gunatilaka\}, \{A. A.\} and Kingston, \{David G.I.\} and Johnson, \{Randall K.\}",

note = "Funding Information: following coworkers; Dr. A. Ahmad, Ms. N. Baj, Prof. V da S. Bolzani, Dr. G.W. Chan, Prof. E. Dagne, Mr. L. Faucette, Mr. T.E. Glass, Dr. G.G. Harrigan, Dr. C.E. Heltzel, Mr. G.A. Hofmann, Prof. J.L. Liang, Dr. Habib-ur-Rehman, Dr. G. Samaranayake and Prof. L.M.M. Valente; we gratefully acknowledge their valuable contributions to this program. The funding for this work was provided by a National Cooperative Drug Discovery Group grant (1 UO1 CA 5077 1) awarded to the University of Virginia (Dr. S.M. Hecht, Principal Investigator).",

year = "1994",

month = jan,

day = "1",

doi = "10.1351/pac199466102219",

language = "English (US)",

volume = "66",

pages = "2219--2222",

journal = "Pure and Applied Chemistry",

issn = "0033-4545",

publisher = "Walter de Gruyter GmbH",

number = "10-11",

}

TY - JOUR

T1 - Mechanism-based isolation and structures of some anticancer active natural products

AU - Leslie Gunatilaka, A. A.

AU - Kingston, David G.I.

AU - Johnson, Randall K.

N1 - Funding Information: following coworkers; Dr. A. Ahmad, Ms. N. Baj, Prof. V da S. Bolzani, Dr. G.W. Chan, Prof. E. Dagne, Mr. L. Faucette, Mr. T.E. Glass, Dr. G.G. Harrigan, Dr. C.E. Heltzel, Mr. G.A. Hofmann, Prof. J.L. Liang, Dr. Habib-ur-Rehman, Dr. G. Samaranayake and Prof. L.M.M. Valente; we gratefully acknowledge their valuable contributions to this program. The funding for this work was provided by a National Cooperative Drug Discovery Group grant (1 UO1 CA 5077 1) awarded to the University of Virginia (Dr. S.M. Hecht, Principal Investigator).

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Application of a mechanism-based anticancer bioassay employing DNA repair-or recombination-deficient mutants of the yeast Saccharomyces cerevisiae for screening and subsequent bioassay-guided fractionation of bioactive higher plant and bryophyte extracts led to the isolation of a variety of natural products with potential anticancer activity. Presented herein are interesting structural features of some representative examples of natural products active in our mechanism-based bioassay and cytotoxicity assays along with structure-activity relationships of synthetic analogs of some of them.

AB - Application of a mechanism-based anticancer bioassay employing DNA repair-or recombination-deficient mutants of the yeast Saccharomyces cerevisiae for screening and subsequent bioassay-guided fractionation of bioactive higher plant and bryophyte extracts led to the isolation of a variety of natural products with potential anticancer activity. Presented herein are interesting structural features of some representative examples of natural products active in our mechanism-based bioassay and cytotoxicity assays along with structure-activity relationships of synthetic analogs of some of them.

UR - https://www.scopus.com/pages/publications/84941838131

UR - https://www.scopus.com/inward/citedby.url?scp=84941838131&partnerID=8YFLogxK

U2 - 10.1351/pac199466102219

DO - 10.1351/pac199466102219

M3 - Article

AN - SCOPUS:84941838131

SN - 0033-4545

VL - 66

SP - 2219

EP - 2222

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

IS - 10-11

ER -

Mechanism-based isolation and structures of some anticancer active natural products

Abstract

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