Mechanism-based isolation and structures of some anticancer active natural products

A. A. Leslie Gunatilaka, David G.I. Kingston, Randall K. Johnson

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Application of a mechanism-based anticancer bioassay employing DNA repair-or recombination-deficient mutants of the yeast Saccharomyces cerevisiae for screening and subsequent bioassay-guided fractionation of bioactive higher plant and bryophyte extracts led to the isolation of a variety of natural products with potential anticancer activity. Presented herein are interesting structural features of some representative examples of natural products active in our mechanism-based bioassay and cytotoxicity assays along with structure-activity relationships of synthetic analogs of some of them.

Original languageEnglish (US)
Pages (from-to)2219-2222
Number of pages4
JournalPure and Applied Chemistry
Issue number10-11
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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