Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering

Qingwei Zhang, Vadym N. Mochalin, Ioannis Neitzel, Kavan Hazeli, Junjie Niu, Antonios Kontsos, Jack G. Zhou, Peter I. Lelkes, Yury Gogotsi

Research output: Contribution to journalArticlepeer-review

162 Scopus citations

Abstract

Multifunctional bone scaffold materials have been produced from a biodegradable polymer, poly(l-lactic acid) (PLLA), and 1-10% wt of octadecylamine-functionalized nanodiamond (ND-ODA) via solution casting followed by compression molding. By comparison to pure PLLA, the addition of 10% wt of ND-ODA resulted in a significant improvement of the mechanical properties of the composite matrix, including a 280% increase in the strain at failure and a 310% increase in fracture energy in tensile tests. The biomimetic process of bonelike apatite growth on the ND-ODA/PLLA scaffolds was studied using microscopic and spectroscopic techniques. The enhanced mechanical properties and the increased mineralization capability with higher ND-ODA concentration suggest that these biodegradable composites may potentially be useful for a variety of biomedical applications, including scaffolds for orthopedic regenerative engineering.

Original languageEnglish (US)
Pages (from-to)5067-5075
Number of pages9
JournalBiomaterials
Volume33
Issue number20
DOIs
StatePublished - Jul 2012
Externally publishedYes

Keywords

  • Biomineralization
  • Bone tissue engineering
  • Mechanical properties
  • Nanocomposite
  • Nanodiamond

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Ceramics and Composites
  • Biomaterials
  • Mechanics of Materials

Fingerprint

Dive into the research topics of 'Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering'. Together they form a unique fingerprint.

Cite this