Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering

Qingwei Zhang; Vadym N. Mochalin; Ioannis Neitzel; Kavan Hazeli; Junjie Niu; Antonios Kontsos; Jack G. Zhou; Peter I. Lelkes; Yury Gogotsi

doi:10.1016/j.biomaterials.2012.03.063

Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering

Qingwei Zhang, Vadym N. Mochalin, Ioannis Neitzel, Kavan Hazeli, Junjie Niu, Antonios Kontsos, Jack G. Zhou, Peter I. Lelkes, Yury Gogotsi

Research output: Contribution to journal › Article › peer-review

213 Scopus citations

Abstract

Multifunctional bone scaffold materials have been produced from a biodegradable polymer, poly(l-lactic acid) (PLLA), and 1-10% wt of octadecylamine-functionalized nanodiamond (ND-ODA) via solution casting followed by compression molding. By comparison to pure PLLA, the addition of 10% wt of ND-ODA resulted in a significant improvement of the mechanical properties of the composite matrix, including a 280% increase in the strain at failure and a 310% increase in fracture energy in tensile tests. The biomimetic process of bonelike apatite growth on the ND-ODA/PLLA scaffolds was studied using microscopic and spectroscopic techniques. The enhanced mechanical properties and the increased mineralization capability with higher ND-ODA concentration suggest that these biodegradable composites may potentially be useful for a variety of biomedical applications, including scaffolds for orthopedic regenerative engineering.

Original language	English (US)
Pages (from-to)	5067-5075
Number of pages	9
Journal	Biomaterials
Volume	33
Issue number	20
DOIs	https://doi.org/10.1016/j.biomaterials.2012.03.063
State	Published - Jul 2012
Externally published	Yes

Keywords

Biomineralization
Bone tissue engineering
Mechanical properties
Nanocomposite
Nanodiamond

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2012.03.063

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title = "Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering",

abstract = "Multifunctional bone scaffold materials have been produced from a biodegradable polymer, poly(l-lactic acid) (PLLA), and 1-10% wt of octadecylamine-functionalized nanodiamond (ND-ODA) via solution casting followed by compression molding. By comparison to pure PLLA, the addition of 10% wt of ND-ODA resulted in a significant improvement of the mechanical properties of the composite matrix, including a 280% increase in the strain at failure and a 310% increase in fracture energy in tensile tests. The biomimetic process of bonelike apatite growth on the ND-ODA/PLLA scaffolds was studied using microscopic and spectroscopic techniques. The enhanced mechanical properties and the increased mineralization capability with higher ND-ODA concentration suggest that these biodegradable composites may potentially be useful for a variety of biomedical applications, including scaffolds for orthopedic regenerative engineering.",

keywords = "Biomineralization, Bone tissue engineering, Mechanical properties, Nanocomposite, Nanodiamond",

author = "Qingwei Zhang and Mochalin, {Vadym N.} and Ioannis Neitzel and Kavan Hazeli and Junjie Niu and Antonios Kontsos and Zhou, {Jack G.} and Lelkes, {Peter I.} and Yury Gogotsi",

note = "Funding Information: We acknowledge support from NSF under the grant number CMMI-0927963 , from the Coulter Foundation, and from the Surgical Engineering Enterprise (SEE) of the Drexel College of Medicine Strategic Initiative. Additionally, the authors are grateful to NanoBlox Inc. for providing the samples of nanodiamond used in this study. We also would like to thank the laboratory of Dr. Yen Wei (Department of Chemistry, Drexel University) for assistance with DSC tests. The Centralized Research Facility (CRF) of the College of Engineering, Drexel University provided access to FTIR, XRD, and the electron microscopes used in this work. Appendix A ",

year = "2012",

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doi = "10.1016/j.biomaterials.2012.03.063",

language = "English (US)",

volume = "33",

pages = "5067--5075",

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TY - JOUR

T1 - Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering

AU - Zhang, Qingwei

AU - Mochalin, Vadym N.

AU - Neitzel, Ioannis

AU - Hazeli, Kavan

AU - Niu, Junjie

AU - Kontsos, Antonios

AU - Zhou, Jack G.

AU - Lelkes, Peter I.

AU - Gogotsi, Yury

N1 - Funding Information: We acknowledge support from NSF under the grant number CMMI-0927963 , from the Coulter Foundation, and from the Surgical Engineering Enterprise (SEE) of the Drexel College of Medicine Strategic Initiative. Additionally, the authors are grateful to NanoBlox Inc. for providing the samples of nanodiamond used in this study. We also would like to thank the laboratory of Dr. Yen Wei (Department of Chemistry, Drexel University) for assistance with DSC tests. The Centralized Research Facility (CRF) of the College of Engineering, Drexel University provided access to FTIR, XRD, and the electron microscopes used in this work. Appendix A

PY - 2012/7

Y1 - 2012/7

N2 - Multifunctional bone scaffold materials have been produced from a biodegradable polymer, poly(l-lactic acid) (PLLA), and 1-10% wt of octadecylamine-functionalized nanodiamond (ND-ODA) via solution casting followed by compression molding. By comparison to pure PLLA, the addition of 10% wt of ND-ODA resulted in a significant improvement of the mechanical properties of the composite matrix, including a 280% increase in the strain at failure and a 310% increase in fracture energy in tensile tests. The biomimetic process of bonelike apatite growth on the ND-ODA/PLLA scaffolds was studied using microscopic and spectroscopic techniques. The enhanced mechanical properties and the increased mineralization capability with higher ND-ODA concentration suggest that these biodegradable composites may potentially be useful for a variety of biomedical applications, including scaffolds for orthopedic regenerative engineering.

AB - Multifunctional bone scaffold materials have been produced from a biodegradable polymer, poly(l-lactic acid) (PLLA), and 1-10% wt of octadecylamine-functionalized nanodiamond (ND-ODA) via solution casting followed by compression molding. By comparison to pure PLLA, the addition of 10% wt of ND-ODA resulted in a significant improvement of the mechanical properties of the composite matrix, including a 280% increase in the strain at failure and a 310% increase in fracture energy in tensile tests. The biomimetic process of bonelike apatite growth on the ND-ODA/PLLA scaffolds was studied using microscopic and spectroscopic techniques. The enhanced mechanical properties and the increased mineralization capability with higher ND-ODA concentration suggest that these biodegradable composites may potentially be useful for a variety of biomedical applications, including scaffolds for orthopedic regenerative engineering.

KW - Biomineralization

KW - Bone tissue engineering

KW - Mechanical properties

KW - Nanocomposite

KW - Nanodiamond

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Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering

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Keywords

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