Measuring the acoustoelectric interaction constant using ultrasound current source density imaging

Qian Li, Ragnar Olafsson, Pier Ingram, Zhaohui Wang, Russell Witte

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Ultrasound current source density imaging (UCSDI) exploits the acoustoelectric (AE) effect, an interaction between ultrasound pressure and electrical resistivity, to map electrical conduction in the heart. The conversion efficiency for UCSDI is determined by the AE interaction constant K, a fundamental property of all materials; K directly affects the magnitude of the detected voltage signal in UCSDI. This paper describes a technique for measuring K in biological tissue, and reports its value for the first time in cadaver hearts. A custom chamber was designed and fabricated to control the geometry for estimating K, which was measured in different ionic salt solutions and seven cadaver rabbit hearts. We found K to be strongly dependent on concentration for the divalent salt CuSO 4, but not for the monovalent salt NaCl, consistent with their different chemical properties. In the rabbit heart, K was determined to be 0.041±0.012%/MPa, similar to the measurement of K in physiological saline (0.034±0.003%/MPa). This study provides a baseline estimate of K for modeling and experimental studies that involve UCSDI to map cardiac conduction and reentry currents associated with arrhythmias.

Original languageEnglish (US)
Article number5929
JournalPhysics in medicine and biology
Issue number19
StatePublished - Oct 7 2012

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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