Measurement depth of laser-induced tissue fluorescence with application to laser angioplasty

Arthur F. Gmitro, Francis W. Cutruzzola, Mark L. Stetz, Lawrence I. Deckelbaum

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Laser-induced fluorescence spectroscopy can be used to discriminate between normal and atherosclerotic tissue and guide the delivery of high-power laser energy for laser angioplasty. The depth of tissue from which fluorescence is measured should closely match the depth of laser ablation and, from a practical standpoint, should be neither too small nor too large. This paper investigates the depth of the fluorescence signal. A simple mathematical model is presented. An experimental procedure for determining this depth is described. The results agree well with the model. The implications of the findings to the development of a practical fluorescence-guided laser angioplasty system are discussed.

Original languageEnglish (US)
Pages (from-to)1844-1849
Number of pages6
JournalApplied optics
Issue number9
StatePublished - May 1988

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering


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