Matrix metalloproteinases and the immune response

Kristina A. Szabo, Richard J. Ablin, Gurmit Singh

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The timely breakdown of the extracellular matrix (ECM) is essential in many physiological and biological processes. The matrix-degradation process involves tissue remodeling and immune/inflammatory reactions that occur in the stroma. Thus, the proteolytic and destructive potential of the matrix metalloproteinase (MMP) family is a major concern in several pathological conditions involving ECM degradation. This review details the structures and functions of MMPs and presents an overview of the interaction of MMPs with components of the immune system.

Original languageEnglish (US)
Pages (from-to)295-319
Number of pages25
JournalClinical and Applied Immunology Reviews
Issue number5
StatePublished - Jul 2004
Externally publishedYes


  • Host Response
  • Immune Cells
  • Inflammation
  • Martix metalloproteinases

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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