Matrix metalloproteinases and the immune response

Kristina A. Szabo; Richard J. Ablin; Gurmit Singh

doi:10.1016/j.cair.2004.02.001

Matrix metalloproteinases and the immune response

Kristina A. Szabo, Richard J. Ablin, Gurmit Singh

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

The timely breakdown of the extracellular matrix (ECM) is essential in many physiological and biological processes. The matrix-degradation process involves tissue remodeling and immune/inflammatory reactions that occur in the stroma. Thus, the proteolytic and destructive potential of the matrix metalloproteinase (MMP) family is a major concern in several pathological conditions involving ECM degradation. This review details the structures and functions of MMPs and presents an overview of the interaction of MMPs with components of the immune system.

Original language	English (US)
Pages (from-to)	295-319
Number of pages	25
Journal	Clinical and Applied Immunology Reviews
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/j.cair.2004.02.001
State	Published - Jul 2004
Externally published	Yes

Keywords

Host Response
Immune Cells
Inflammation
Martix metalloproteinases

ASJC Scopus subject areas

Microbiology
Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.cair.2004.02.001

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title = "Matrix metalloproteinases and the immune response",

abstract = "The timely breakdown of the extracellular matrix (ECM) is essential in many physiological and biological processes. The matrix-degradation process involves tissue remodeling and immune/inflammatory reactions that occur in the stroma. Thus, the proteolytic and destructive potential of the matrix metalloproteinase (MMP) family is a major concern in several pathological conditions involving ECM degradation. This review details the structures and functions of MMPs and presents an overview of the interaction of MMPs with components of the immune system.",

keywords = "Host Response, Immune Cells, Inflammation, Martix metalloproteinases",

author = "Szabo, {Kristina A.} and Ablin, {Richard J.} and Gurmit Singh",

note = "Funding Information: This work was supported by a grant from the Canadian Institutes of Health Research (CIHR).",

year = "2004",

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doi = "10.1016/j.cair.2004.02.001",

language = "English (US)",

volume = "4",

pages = "295--319",

journal = "Clinical and Applied Immunology Reviews",

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TY - JOUR

T1 - Matrix metalloproteinases and the immune response

AU - Szabo, Kristina A.

AU - Ablin, Richard J.

AU - Singh, Gurmit

N1 - Funding Information: This work was supported by a grant from the Canadian Institutes of Health Research (CIHR).

PY - 2004/7

Y1 - 2004/7

N2 - The timely breakdown of the extracellular matrix (ECM) is essential in many physiological and biological processes. The matrix-degradation process involves tissue remodeling and immune/inflammatory reactions that occur in the stroma. Thus, the proteolytic and destructive potential of the matrix metalloproteinase (MMP) family is a major concern in several pathological conditions involving ECM degradation. This review details the structures and functions of MMPs and presents an overview of the interaction of MMPs with components of the immune system.

AB - The timely breakdown of the extracellular matrix (ECM) is essential in many physiological and biological processes. The matrix-degradation process involves tissue remodeling and immune/inflammatory reactions that occur in the stroma. Thus, the proteolytic and destructive potential of the matrix metalloproteinase (MMP) family is a major concern in several pathological conditions involving ECM degradation. This review details the structures and functions of MMPs and presents an overview of the interaction of MMPs with components of the immune system.

KW - Host Response

KW - Immune Cells

KW - Inflammation

KW - Martix metalloproteinases

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U2 - 10.1016/j.cair.2004.02.001

DO - 10.1016/j.cair.2004.02.001

M3 - Review article

AN - SCOPUS:3242776237

SN - 1529-1049

VL - 4

SP - 295

EP - 319

JO - Clinical and Applied Immunology Reviews

JF - Clinical and Applied Immunology Reviews

IS - 5

ER -

Matrix metalloproteinases and the immune response

Abstract

Keywords

ASJC Scopus subject areas

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