Maternal Protein Deprivation: Changes in Systemic Renin-Angiotensin System of the Mouse Fetus

Ravi Goyal, Andrew Galffy, Stephanie A. Field, Ciprian P. Gheorghe, Ashwani Mittal, Lawrence D. Longo

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We tested the hypothesis that maternal protein deprivation during gestation results in changes in expression of the systemic renin-angiotensin system in fetal mice. Fetal weight was decreased significantly as a consequence of 50% maternal protein deprivation during second half of gestation. In fetal liver, angiotensinogen protein expression was reduced significantly despite a significant increase in messenger RNA (mRNA). In fetal kidneys, both mRNA and protein levels of renin were increased significantly. In the lungs, we observed a decrease in both angiotensin-converting enzyme I and II mRNA expression, whereas protein expression of both isoforms was increased significantly. The fetal heart showed significant increases in expression of angiotensin II type 1 (AT-1) and type 2 (AT-2) receptors mRNA. Protein expression of AT-1 receptors increased, while that of AT-2 receptors decreased. We conclude that maternal low-protein diet during gestation leads to significant changes in expression of the systemic renin-angiotensin system in fetal mice and may be important in the genesis of hypertension in the adult.

Original languageEnglish (US)
Pages (from-to)894-904
Number of pages11
JournalReproductive Sciences
Volume16
Issue number9
DOIs
StatePublished - Sep 2009
Externally publishedYes

Keywords

  • Hypertension
  • development
  • fetal growth
  • gene expression

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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