Maternal phenylketonuria: Implications for growth and development

William K. Frankenburg, Burris R. Duncan, R. Wendell Coffelt, Richard Koch, James G. Coldwell, Choon D. Son

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Eight non-PKU offspring of phenylketonuric mothers are described. All of the patients have mental subnormality and I.Q./D.Q. scores below those of their mothers. Phenylalanine loading tests failed to discriminate between the nonheterozygotes and the heterozygotes. Growth data from these cases and additional previously unpublished growth data on 13 non-PKU offspring of 3 phenylketonuric mothers demonstrated uniform intrauterine and postnatal growth retardation.

Original languageEnglish (US)
Pages (from-to)560-570
Number of pages11
JournalThe Journal of Pediatrics
Issue number4
StatePublished - Oct 1968
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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