Maternal phenylketonuria: Implications for growth and development

William K. Frankenburg; Burris R. Duncan; R. Wendell Coffelt; Richard Koch; James G. Coldwell; Choon D. Son

doi:10.1016/S0022-3476(68)80271-9

Maternal phenylketonuria: Implications for growth and development

William K. Frankenburg, Burris R. Duncan, R. Wendell Coffelt, Richard Koch, James G. Coldwell, Choon D. Son

Research output: Contribution to journal › Article › peer-review

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Abstract

Eight non-PKU offspring of phenylketonuric mothers are described. All of the patients have mental subnormality and I.Q./D.Q. scores below those of their mothers. Phenylalanine loading tests failed to discriminate between the nonheterozygotes and the heterozygotes. Growth data from these cases and additional previously unpublished growth data on 13 non-PKU offspring of 3 phenylketonuric mothers demonstrated uniform intrauterine and postnatal growth retardation.

Original language	English (US)
Pages (from-to)	560-570
Number of pages	11
Journal	The Journal of Pediatrics
Volume	73
Issue number	4
DOIs	https://doi.org/10.1016/S0022-3476(68)80271-9
State	Published - Oct 1968
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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@article{5551201c83d0459eb2682eaca5e79116,

title = "Maternal phenylketonuria: Implications for growth and development",

abstract = "Eight non-PKU offspring of phenylketonuric mothers are described. All of the patients have mental subnormality and I.Q./D.Q. scores below those of their mothers. Phenylalanine loading tests failed to discriminate between the nonheterozygotes and the heterozygotes. Growth data from these cases and additional previously unpublished growth data on 13 non-PKU offspring of 3 phenylketonuric mothers demonstrated uniform intrauterine and postnatal growth retardation.",

author = "Frankenburg, {William K.} and Duncan, {Burris R.} and Coffelt, {R. Wendell} and Richard Koch and Coldwell, {James G.} and Son, {Choon D.}",

note = "Funding Information: Supported by grants from the United States Public Health Service, National Institute of Child Health and Human Development, Grant No. HD.O0318; Children's Bureau, Project Nos. 441, 309, and 252, and Maternal-Child Health Grant to Wyoming State Department of Public Health; National Foundation, Birth Defects Special Treatment Center, Grants Nos. C-26 and C-29.",

year = "1968",

month = oct,

doi = "10.1016/S0022-3476(68)80271-9",

language = "English (US)",

volume = "73",

pages = "560--570",

journal = "The Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

number = "4",

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TY - JOUR

T1 - Maternal phenylketonuria

T2 - Implications for growth and development

AU - Frankenburg, William K.

AU - Duncan, Burris R.

AU - Coffelt, R. Wendell

AU - Koch, Richard

AU - Coldwell, James G.

AU - Son, Choon D.

N1 - Funding Information: Supported by grants from the United States Public Health Service, National Institute of Child Health and Human Development, Grant No. HD.O0318; Children's Bureau, Project Nos. 441, 309, and 252, and Maternal-Child Health Grant to Wyoming State Department of Public Health; National Foundation, Birth Defects Special Treatment Center, Grants Nos. C-26 and C-29.

PY - 1968/10

Y1 - 1968/10

N2 - Eight non-PKU offspring of phenylketonuric mothers are described. All of the patients have mental subnormality and I.Q./D.Q. scores below those of their mothers. Phenylalanine loading tests failed to discriminate between the nonheterozygotes and the heterozygotes. Growth data from these cases and additional previously unpublished growth data on 13 non-PKU offspring of 3 phenylketonuric mothers demonstrated uniform intrauterine and postnatal growth retardation.

AB - Eight non-PKU offspring of phenylketonuric mothers are described. All of the patients have mental subnormality and I.Q./D.Q. scores below those of their mothers. Phenylalanine loading tests failed to discriminate between the nonheterozygotes and the heterozygotes. Growth data from these cases and additional previously unpublished growth data on 13 non-PKU offspring of 3 phenylketonuric mothers demonstrated uniform intrauterine and postnatal growth retardation.

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JO - The Journal of Pediatrics

JF - The Journal of Pediatrics

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Maternal phenylketonuria: Implications for growth and development

Abstract

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