Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy

Dae Hyeong Kim; Nanshu Lu; Roozbeh Ghaffari; Yun Soung Kim; Stephen P. Lee; Lizhi Xu; Jian Wu; Rak Hwan Kim; Jizhou Song; Zhuangjian Liu; Jonathan Viventi; Bassel De Graff; Brian Elolampi; Moussa Mansour; Marvin J. Slepian; Sukwon Hwang; Joshua D. Moss; Sang Min Won; Younggang Huang; Brian Litt; John A. Rogers

doi:10.1038/nmat2971

Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy

Dae Hyeong Kim, Nanshu Lu, Roozbeh Ghaffari, Yun Soung Kim, Stephen P. Lee, Lizhi Xu, Jian Wu, Rak Hwan Kim, Jizhou Song, Zhuangjian Liu, Jonathan Viventi, Bassel De Graff, Brian Elolampi, Moussa Mansour, Marvin J. Slepian, Sukwon Hwang, Joshua D. Moss, Sang Min Won, Younggang Huang, Brian LittJohn A. Rogers

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703 Scopus citations

Abstract

Developing advanced surgical tools for minimally invasive procedures represents an activity of central importance to improving human health. A key challenge is in establishing biocompatible interfaces between the classes of semiconductor device and sensor technologies that might be most useful in this context and the soft, curvilinear surfaces of the body. This paper describes a solution based on materials that integrate directly with the thin elastic membranes of otherwise conventional balloon catheters, to provide diverse, multimodal functionality suitable for clinical use. As examples, we present sensors for measuring temperature, flow, tactile, optical and electrophysiological data, together with radiofrequency electrodes for controlled, local ablation of tissue. Use of such instrumented balloon catheters in live animal models illustrates their operation, as well as their specific utility in cardiac ablation therapy. The same concepts can be applied to other substrates of interest, such as surgical gloves.

Original language	English (US)
Pages (from-to)	316-323
Number of pages	8
Journal	Nature materials
Volume	10
Issue number	4
DOIs	https://doi.org/10.1038/nmat2971
State	Published - Apr 2011

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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Kim, D. H., Lu, N., Ghaffari, R., Kim, Y. S., Lee, S. P., Xu, L., Wu, J., Kim, R. H., Song, J., Liu, Z., Viventi, J., De Graff, B., Elolampi, B., Mansour, M., Slepian, M. J., Hwang, S., Moss, J. D., Won, S. M., Huang, Y., ... Rogers, J. A. (2011). Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy. Nature materials, 10(4), 316-323. https://doi.org/10.1038/nmat2971

Kim, DH, Lu, N, Ghaffari, R, Kim, YS, Lee, SP, Xu, L, Wu, J, Kim, RH, Song, J, Liu, Z, Viventi, J, De Graff, B, Elolampi, B, Mansour, M, Slepian, MJ, Hwang, S, Moss, JD, Won, SM, Huang, Y, Litt, B & Rogers, JA 2011, 'Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy', Nature materials, vol. 10, no. 4, pp. 316-323. https://doi.org/10.1038/nmat2971

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title = "Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy",

abstract = "Developing advanced surgical tools for minimally invasive procedures represents an activity of central importance to improving human health. A key challenge is in establishing biocompatible interfaces between the classes of semiconductor device and sensor technologies that might be most useful in this context and the soft, curvilinear surfaces of the body. This paper describes a solution based on materials that integrate directly with the thin elastic membranes of otherwise conventional balloon catheters, to provide diverse, multimodal functionality suitable for clinical use. As examples, we present sensors for measuring temperature, flow, tactile, optical and electrophysiological data, together with radiofrequency electrodes for controlled, local ablation of tissue. Use of such instrumented balloon catheters in live animal models illustrates their operation, as well as their specific utility in cardiac ablation therapy. The same concepts can be applied to other substrates of interest, such as surgical gloves.",

author = "Kim, {Dae Hyeong} and Nanshu Lu and Roozbeh Ghaffari and Kim, {Yun Soung} and Lee, {Stephen P.} and Lizhi Xu and Jian Wu and Kim, {Rak Hwan} and Jizhou Song and Zhuangjian Liu and Jonathan Viventi and {De Graff}, Bassel and Brian Elolampi and Moussa Mansour and Slepian, {Marvin J.} and Sukwon Hwang and Moss, {Joshua D.} and Won, {Sang Min} and Younggang Huang and Brian Litt and Rogers, {John A.}",

note = "Funding Information: We thank K. Dowling for help in high-resolution imaging and analysis of devices. We thank B. Dehdashti and members of the Sarver Heart Center for help in preparing the animals for in vivo studies. We thank S. Laferriere and the Massachusetts General Hospital Electrophysiology Laboratory for help with X-ray imaging in animals. This material is based on work supported by the National Science Foundation under grant DMI-0328162 and the US Department of Energy, Division of Materials Sciences, under award DE-FG02-07ER46471, through the Materials Research Laboratory and Center for Microanalysis of Materials (DE-FG02-07ER46453) at the University of Illinois at Urbana-Champaign. N.L. acknowledges support from a Beckman Institute postdoctoral fellowship. J.A.R. acknowledges a National Security Science and Engineering Faculty Fellowship.",

year = "2011",

month = apr,

doi = "10.1038/nmat2971",

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AU - Kim, Dae Hyeong

AU - Lu, Nanshu

AU - Ghaffari, Roozbeh

AU - Kim, Yun Soung

AU - Lee, Stephen P.

AU - Xu, Lizhi

AU - Wu, Jian

AU - Kim, Rak Hwan

AU - Song, Jizhou

AU - Liu, Zhuangjian

AU - Viventi, Jonathan

AU - De Graff, Bassel

AU - Elolampi, Brian

AU - Mansour, Moussa

AU - Slepian, Marvin J.

AU - Hwang, Sukwon

AU - Moss, Joshua D.

AU - Won, Sang Min

AU - Huang, Younggang

AU - Litt, Brian

AU - Rogers, John A.

N1 - Funding Information: We thank K. Dowling for help in high-resolution imaging and analysis of devices. We thank B. Dehdashti and members of the Sarver Heart Center for help in preparing the animals for in vivo studies. We thank S. Laferriere and the Massachusetts General Hospital Electrophysiology Laboratory for help with X-ray imaging in animals. This material is based on work supported by the National Science Foundation under grant DMI-0328162 and the US Department of Energy, Division of Materials Sciences, under award DE-FG02-07ER46471, through the Materials Research Laboratory and Center for Microanalysis of Materials (DE-FG02-07ER46453) at the University of Illinois at Urbana-Champaign. N.L. acknowledges support from a Beckman Institute postdoctoral fellowship. J.A.R. acknowledges a National Security Science and Engineering Faculty Fellowship.

PY - 2011/4

Y1 - 2011/4

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AB - Developing advanced surgical tools for minimally invasive procedures represents an activity of central importance to improving human health. A key challenge is in establishing biocompatible interfaces between the classes of semiconductor device and sensor technologies that might be most useful in this context and the soft, curvilinear surfaces of the body. This paper describes a solution based on materials that integrate directly with the thin elastic membranes of otherwise conventional balloon catheters, to provide diverse, multimodal functionality suitable for clinical use. As examples, we present sensors for measuring temperature, flow, tactile, optical and electrophysiological data, together with radiofrequency electrodes for controlled, local ablation of tissue. Use of such instrumented balloon catheters in live animal models illustrates their operation, as well as their specific utility in cardiac ablation therapy. The same concepts can be applied to other substrates of interest, such as surgical gloves.

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Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy

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