TY - JOUR
T1 - Maps, Codes, and Sequence Elements
T2 - Can We Predict the Protein Output from an Alternatively Spliced Locus?
AU - Sharma, Shalini
AU - Black, Douglas L.
PY - 2006/11/22
Y1 - 2006/11/22
N2 - Alternative splicing choices are governed by splicing regulatory protein interactions with splicing silencer and enhancer elements present in the pre-mRNA. However, the prediction of these choices from genomic sequence is difficult, in part because the regulators can act as either enhancers or silencers. A recent study describes how for a particular neuronal splicing regulatory protein, Nova, the location of its binding sites is highly predictive of the protein's effect on an exon's splicing.
AB - Alternative splicing choices are governed by splicing regulatory protein interactions with splicing silencer and enhancer elements present in the pre-mRNA. However, the prediction of these choices from genomic sequence is difficult, in part because the regulators can act as either enhancers or silencers. A recent study describes how for a particular neuronal splicing regulatory protein, Nova, the location of its binding sites is highly predictive of the protein's effect on an exon's splicing.
UR - http://www.scopus.com/inward/record.url?scp=33750967916&partnerID=8YFLogxK
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U2 - 10.1016/j.neuron.2006.11.005
DO - 10.1016/j.neuron.2006.11.005
M3 - Short survey
C2 - 17114042
AN - SCOPUS:33750967916
SN - 0896-6273
VL - 52
SP - 574
EP - 576
JO - Neuron
JF - Neuron
IS - 4
ER -