Mapping single-cell-substrate interactions by surface plasmon resonance microscopy

Wei Wang, Shaopeng Wang, Qiang Liu, Jie Wu, Nongjian Tao

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


We report the imaging of the cell-substrate adhesion of a single cell with subcellular spatial resolution. Osmotic pressure was introduced to provide a controllable mechanical stimulation to the cell attached to a substrate, and high-resolution surface plasmon resonance microscopy was used to map the response of the cell, from which local cell-substrate adhesion was determined. In addition to high spatial resolution, the approach is noninvasive and fast and allows for the continuous mapping of cell-substrate interactions and single-cell movements.

Original languageEnglish (US)
Pages (from-to)13373-13379
Number of pages7
Issue number37
StatePublished - Sep 18 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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