Manganese-based liposomes comparative approaches

Evan Unger, Thomas Fritz, De Kang Shen, Guanli Wu

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


RATIONALE AND OBJECTIVES. The purpose of this study was to further develop and compare manganese-based liposomes prepared by two different approaches wherein a manganese ion was entrapped within the internal aqueous space of the vesicles or into the bilayer surface via membrane bound complexes. METHODS. Small unilamellar liposomes (SUVs) were prepared entrapping manganese chloride. Alkylated complexes of manganese were prepared and also incorporated into SUVs. The two different manganese-based liposomes were compared for in-vitro relaxivity, stability, toxicity, and in-vivo imaging in rats with liver tumors. RESULTS. Liposomes entrapping manganese had a concentration-dependent change in relaxivity that was maximal at a several-fold molar excess of phospholipid relative to manganese ion. Liposomes bearing membrane-bound complexes showed relaxivity inversely proportional to vesicle size. In-vivo imaging showed greater and more specific hepatic enhancement with manganese liposomes bearing alkylated complexes than those entrapping manganese ion. CONCLUSIONS. Correlation effects likely explain the increased relaxivity of manganese entrapped in phospholipid vesicles. Greater efficacy, however, is afforded by liposomes bearing alkylated complexes.

Original languageEnglish (US)
Pages (from-to)933-938
Number of pages6
JournalInvestigative Radiology
Issue number10
StatePublished - Oct 1993
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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