Management of bone metastases in breast cancer

Ursa Brown-Glaberman, Alison T. Stopeck

Research output: Chapter in Book/Report/Conference proceedingChapter


Managing patients with bone metastases requires a multidisciplinary approach applying the expertise of orthopedic surgeons, radiation oncologists, medical oncologists, and radiologists. Small lesions can usually be successfully treated with radiation therapy alone, with subsequent surgical stabilization only for continued symptoms or fracture. Bones with diffuse, permeative destruction should be internally stabilized prophylactically if possible, followed by postoperative radiation therapy. Unless contraindicated, all patients with metastatic carcinoma of the breast with involvement of the bone should receive systemic osteoclast inhibitor therapy for the prevention of skeletal related events, irrespective of pain symptoms or extent of disease. Future treatment modalities will further decrease the substantial morbidity associated with the development and progression of bone metastases.

Original languageEnglish (US)
Title of host publicationThe Breast
Subtitle of host publicationComprehensive Management of Benign and Malignant Diseases
PublisherElsevier Inc.
ISBN (Print)9780323359559
StatePublished - 2018
Externally publishedYes


  • Bone metastases
  • Bone pain
  • Breast cancer
  • Pathologic fracture
  • Skeletal related events

ASJC Scopus subject areas

  • Medicine(all)


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