TY - JOUR
T1 - Malignant pheochromocytoma
T2 - Effective treatment with a combination of cyclophosphamide, vincristine, and dacarbazine
AU - Averbuch, S. D.
AU - Steakley, C. S.
AU - Young, R. C.
AU - Gelmann, E. P.
AU - Goldstein, D. S.
AU - Stull, R.
AU - Keiser, H. R.
PY - 1988
Y1 - 1988
N2 - Study Objective: To determine the efficacy and toxicity of combination chemotherapy in patients with advanced, malignant pheochromocytoma. Design: Nonrandomized, single-arm trial. Setting: Governmental medical referral center. Patients: Fourteen patients with malignant pheochromocytoma confirmed by histologic tests. All patients had metastatic disease and elevated urinary catecholamine secretion. Interventions: After optimization of antihypertensive therapy, patients received cyclophosphamide, 750 mg/m2 body surface area on day 1; vincristine, 1.4 mg/m2 on day 1, and dacarbazine, 600 mg/m2 on days 1 and 2, every 21 days. Measurements and Main Results: Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine produced a complete and partial response rate of 57% (median duration, 21 months; range, 7 to more than 34). Complete and partial biochemical responses were seen in 79% of patients (median duration, more than 22 months; range, 6 to more than 35). All responding patients had objective improvement in performance status and blood pressure. Toxicity included expected hematologic, neurologic, and gastrointestinal effects of chemotherapy without serious sequelae. There were four minor hypotensive episodes and one minor hypertensive episode. Conclusions: Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine is effective for advanced malignant pheochromocytoma. Urinary catecholamines are useful to ascertain biochemical response to therapy.
AB - Study Objective: To determine the efficacy and toxicity of combination chemotherapy in patients with advanced, malignant pheochromocytoma. Design: Nonrandomized, single-arm trial. Setting: Governmental medical referral center. Patients: Fourteen patients with malignant pheochromocytoma confirmed by histologic tests. All patients had metastatic disease and elevated urinary catecholamine secretion. Interventions: After optimization of antihypertensive therapy, patients received cyclophosphamide, 750 mg/m2 body surface area on day 1; vincristine, 1.4 mg/m2 on day 1, and dacarbazine, 600 mg/m2 on days 1 and 2, every 21 days. Measurements and Main Results: Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine produced a complete and partial response rate of 57% (median duration, 21 months; range, 7 to more than 34). Complete and partial biochemical responses were seen in 79% of patients (median duration, more than 22 months; range, 6 to more than 35). All responding patients had objective improvement in performance status and blood pressure. Toxicity included expected hematologic, neurologic, and gastrointestinal effects of chemotherapy without serious sequelae. There were four minor hypotensive episodes and one minor hypertensive episode. Conclusions: Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine is effective for advanced malignant pheochromocytoma. Urinary catecholamines are useful to ascertain biochemical response to therapy.
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U2 - 10.7326/0003-4819-109-4-267
DO - 10.7326/0003-4819-109-4-267
M3 - Article
C2 - 3395037
AN - SCOPUS:0023789889
SN - 0003-4819
VL - 109
SP - 267
EP - 273
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 4
ER -