Malignant melanoma arising in a primary mediastinal germ cell tumor

Sherry Lee; Yevgen Chornenkyy; Michael T. Swete; Samuel S. Kim; Ankit Bharat; Ximing J. Yang; Anjana Yeldandi

doi:10.1016/j.prp.2020.153210

Malignant melanoma arising in a primary mediastinal germ cell tumor

Sherry Lee, Yevgen Chornenkyy, Michael T. Swete, Samuel S. Kim, Ankit Bharat, Ximing J. Yang, Anjana Yeldandi

Surgery

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4 Scopus citations

Abstract

Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histopathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.

Original language	English (US)
Article number	153210
Journal	Pathology Research and Practice
Volume	216
Issue number	11
DOIs	https://doi.org/10.1016/j.prp.2020.153210
State	Published - Nov 2020

Keywords

KIT
Mediastinal germ cell tumor
Melanoma
Molecular analysis
NRAS
Teratoma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cell Biology

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10.1016/j.prp.2020.153210

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title = "Malignant melanoma arising in a primary mediastinal germ cell tumor",

abstract = "Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histopathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.",

keywords = "KIT, Mediastinal germ cell tumor, Melanoma, Molecular analysis, NRAS, Teratoma",

author = "Sherry Lee and Yevgen Chornenkyy and Swete, {Michael T.} and Kim, {Samuel S.} and Ankit Bharat and Yang, {Ximing J.} and Anjana Yeldandi",

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year = "2020",

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doi = "10.1016/j.prp.2020.153210",

language = "English (US)",

volume = "216",

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T1 - Malignant melanoma arising in a primary mediastinal germ cell tumor

AU - Lee, Sherry

AU - Chornenkyy, Yevgen

AU - Swete, Michael T.

AU - Kim, Samuel S.

AU - Bharat, Ankit

AU - Yang, Ximing J.

AU - Yeldandi, Anjana

PY - 2020/11

Y1 - 2020/11

N2 - Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histopathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.

AB - Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histopathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.

KW - KIT

KW - Mediastinal germ cell tumor

KW - Melanoma

KW - Molecular analysis

KW - NRAS

KW - Teratoma

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JO - Pathology Research and Practice

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IS - 11

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ER -

Malignant melanoma arising in a primary mediastinal germ cell tumor

Abstract

Keywords

ASJC Scopus subject areas

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