Abstract
Crystal structures of the homing endonuclease I-CreI bound to substrate DNA and divalent metals show that one metal ion is shared between the two active sites of the enzyme. This arrangement appears uniquely suited to the formation of double-stranded DNA breaks via a concerted reaction.
Original language | English (US) |
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Pages (from-to) | 290-293 |
Number of pages | 4 |
Journal | Nature Structural Biology |
Volume | 8 |
Issue number | 4 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Genetics