Making the most of metal ions

N. C. Horton, J. J. Perona

Research output: Contribution to journalShort surveypeer-review

44 Scopus citations


Crystal structures of the homing endonuclease I-CreI bound to substrate DNA and divalent metals show that one metal ion is shared between the two active sites of the enzyme. This arrangement appears uniquely suited to the formation of double-stranded DNA breaks via a concerted reaction.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalNature Structural Biology
Issue number4
StatePublished - 2001

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics


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