Major review: Exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology

Inas F. Aboobakar, William M. Johnson, W. Daniel Stamer, Michael A. Hauser, R. Rand Allingham

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations

Abstract

Exfoliation syndrome (XFS) is a common age-related disorder that leads to deposition of extracellular fibrillar material throughout the body. The most recognized disease manifestation is exfoliation glaucoma (XFG), which is a common cause of blindness worldwide. Recent developments in XFS genetics, cell biology and epidemiology have greatly improved our understanding of the etiology of this complex inherited disease. This review summarizes current knowledge of XFS pathogenesis, identifies gaps in knowledge, and discusses areas for future research.

Original languageEnglish (US)
Pages (from-to)88-103
Number of pages16
JournalExperimental eye research
Volume154
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • CACNA1A
  • Exfoliation syndrome
  • Gene-environment interaction
  • Glaucoma
  • GWAS
  • Homocysteine
  • LOXL1
  • Pseudoexfoliation
  • TGF-β1

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'Major review: Exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology'. Together they form a unique fingerprint.

Cite this