Major recessive gene(s) with considerable residual polygenic effect regulating adult height: Confirmation of genomewide scan results for chromosomes 6, 9, and 12

Jianfeng Xu, Eugene R. Bleecker, Hajo Jongepier, Timothy D. Howard, Gerard H. Koppelman, Dirkje S. Postma, Deborah A. Meyers

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.

Original languageEnglish (US)
Pages (from-to)646-650
Number of pages5
JournalAmerican Journal of Human Genetics
Volume71
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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