TY - JOUR
T1 - Major recessive gene(s) with considerable residual polygenic effect regulating adult height
T2 - Confirmation of genomewide scan results for chromosomes 6, 9, and 12
AU - Xu, Jianfeng
AU - Bleecker, Eugene R.
AU - Jongepier, Hajo
AU - Howard, Timothy D.
AU - Koppelman, Gerard H.
AU - Postma, Dirkje S.
AU - Meyers, Deborah A.
N1 - Funding Information:
We thank all of the families whose participation made this project possible. This work was supported by Dutch Asthma Funds grant AF 95.09 and by National Institutes of Health grants R01-HL48341 and R01-HL66393. Some of the results of this article were obtained by use of the program package S.A.G.E., which is supported by U.S. Public Health Service Resource grant 1-P41-RR03655 from the National Center for Research Resources.
PY - 2002
Y1 - 2002
N2 - Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.
AB - Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.
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U2 - 10.1086/342216
DO - 10.1086/342216
M3 - Article
C2 - 12119602
AN - SCOPUS:0036724841
SN - 0002-9297
VL - 71
SP - 646
EP - 650
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 3
ER -