TY - JOUR
T1 - Magnitude and regional distribution of cartilage loss associated with grades of joint space narrowing in radiographic osteoarthritis - data from the Osteoarthritis Initiative (OAI)
AU - Eckstein, F.
AU - Wirth, W.
AU - Hunter, D. J.
AU - Guermazi, A.
AU - Kwoh, C. K.
AU - Nelson, D. R.
AU - Benichou, O.
N1 - Funding Information:
Funding sources: The image analysis of this study was funded by Eli Lilly & Co, IN . The images were acquired by the OAI, a public–private partnership comprised five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institute of Health , a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners of the OAI include Merck Research Laboratories ; Novartis Pharmaceuticals Corporation , GlaxoSmithKline ; and Pfizer, Inc . Private sector funding for the OAI is managed by the Foundation for the National Institute of Health . This manuscript has received the approval of the OAI Publications Committee based on a review of its scientific content and data interpretation.
PY - 2010/6
Y1 - 2010/6
N2 - Objective: Clinically, radiographic joint space narrowing (JSN) is regarded a surrogate of cartilage loss in osteoarthritis (OA). Using magnetic resonance imaging (MRI), we explored the magnitude and regional distribution of differences in cartilage thickness and subchondral bone area associated with specific Osteoarthritis Research Society International (OARSI) JSN grades. Method: Seventy-three participants with unilateral medial JSN were selected from the first half (2678 cases) of the OA Initiative cohort (45, 21, and 7 with OARSI JSN grades 1, 2, and 3, respectively, no medial JSN in the contra-lateral knee). Bilateral sagittal baseline DESSwe MRIs were segmented by experienced operators. Intra-person between-knee differences in cartilage thickness and subchondral bone areas were determined in medial femorotibial subregions. Results: Knees with medial OARSI JSN grades 1, 2, and 3 displayed a 190μm (5.2%), 630μm (18%), and 1560μm (44%) smaller cartilage thickness in weight-bearing medial femorotibial compartments compared to knees without JSN, respectively. The weight-bearing femoral condyle displayed relatively greater differences than the posterior femoral condyle or the medial tibia (MT). The central subregion within the weight-bearing medial femur (cMF) of the femoral condyle (30-75°), and the external and central subregions within the tibia displayed relatively greater JSN-associated differences compared to other medial femorotibial subregions. Knees with higher JSN grades also displayed larger than contra-lateral femorotibial subchondral bone areas. Conclusions: This study provides quantitative estimates of JSN-related cartilage loss, with the central part of the weight-bearing femoral condyle being most strongly affected. Knees with higher JSN grades displayed larger subchondral bone areas, suggesting that an increase in subchondral bone area occurs in advanced OA.
AB - Objective: Clinically, radiographic joint space narrowing (JSN) is regarded a surrogate of cartilage loss in osteoarthritis (OA). Using magnetic resonance imaging (MRI), we explored the magnitude and regional distribution of differences in cartilage thickness and subchondral bone area associated with specific Osteoarthritis Research Society International (OARSI) JSN grades. Method: Seventy-three participants with unilateral medial JSN were selected from the first half (2678 cases) of the OA Initiative cohort (45, 21, and 7 with OARSI JSN grades 1, 2, and 3, respectively, no medial JSN in the contra-lateral knee). Bilateral sagittal baseline DESSwe MRIs were segmented by experienced operators. Intra-person between-knee differences in cartilage thickness and subchondral bone areas were determined in medial femorotibial subregions. Results: Knees with medial OARSI JSN grades 1, 2, and 3 displayed a 190μm (5.2%), 630μm (18%), and 1560μm (44%) smaller cartilage thickness in weight-bearing medial femorotibial compartments compared to knees without JSN, respectively. The weight-bearing femoral condyle displayed relatively greater differences than the posterior femoral condyle or the medial tibia (MT). The central subregion within the weight-bearing medial femur (cMF) of the femoral condyle (30-75°), and the external and central subregions within the tibia displayed relatively greater JSN-associated differences compared to other medial femorotibial subregions. Knees with higher JSN grades also displayed larger than contra-lateral femorotibial subchondral bone areas. Conclusions: This study provides quantitative estimates of JSN-related cartilage loss, with the central part of the weight-bearing femoral condyle being most strongly affected. Knees with higher JSN grades displayed larger subchondral bone areas, suggesting that an increase in subchondral bone area occurs in advanced OA.
KW - Cartilage loss
KW - Joint space narrowing
KW - Magnetic resonance imaging
KW - Radiographic osteoarthritis
KW - Side comparison
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U2 - 10.1016/j.joca.2009.12.009
DO - 10.1016/j.joca.2009.12.009
M3 - Article
C2 - 20171298
AN - SCOPUS:77952877015
SN - 1063-4584
VL - 18
SP - 760
EP - 768
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 6
ER -