Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

Hua Ai; Christopher Flask; Brent Weinberg; Xintao Shuai; Many D. Pagel; David Farrell; Jeffrey Duerk; Jinming Gao

doi:10.1002/adma.200401904

Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

Hua Ai, Christopher Flask, Brent Weinberg, Xintao Shuai, Many D. Pagel, David Farrell, Jeffrey Duerk, Jinming Gao

Research output: Contribution to journal › Article › peer-review

435 Scopus citations

Abstract

The development of super-paramagnetic polymer micelles as a new class of magnetic resonance imaging (MRI) probes with high spin-spin relaxivity and sensitivity, was reported. The micelles consists of a cluster of hydrophobic magnetite particles encapsulated inside the hydrophobic core of polymeric micelle whose surface is stabilized by a poly(ethylene glycol) (PEG) shell. The unique core-shell composite design helps to achieve an ultrasensitive MRI detection limit of 5.2 μgmL^-1, and promises for an application in molecular imaging and image-visible drug delivery applications. An amphiphilic diblock copolymer of poly(η-caprolactone)-b-polyethylene glycol was used in the study.

Original language	English (US)
Pages (from-to)	1949-1952
Number of pages	4
Journal	Advanced Materials
Volume	17
Issue number	16
DOIs	https://doi.org/10.1002/adma.200401904
State	Published - Aug 18 2005
Externally published	Yes

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.200401904

Cite this

@article{dc31aafe902b4429bdb1a03022ae45d5,

title = "Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes",

abstract = "The development of super-paramagnetic polymer micelles as a new class of magnetic resonance imaging (MRI) probes with high spin-spin relaxivity and sensitivity, was reported. The micelles consists of a cluster of hydrophobic magnetite particles encapsulated inside the hydrophobic core of polymeric micelle whose surface is stabilized by a poly(ethylene glycol) (PEG) shell. The unique core-shell composite design helps to achieve an ultrasensitive MRI detection limit of 5.2 μgmL-1, and promises for an application in molecular imaging and image-visible drug delivery applications. An amphiphilic diblock copolymer of poly(η-caprolactone)-b-polyethylene glycol was used in the study.",

author = "Hua Ai and Christopher Flask and Brent Weinberg and Xintao Shuai and Pagel, {Many D.} and David Farrell and Jeffrey Duerk and Jinming Gao",

year = "2005",

month = aug,

day = "18",

doi = "10.1002/adma.200401904",

language = "English (US)",

volume = "17",

pages = "1949--1952",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "16",

}

TY - JOUR

T1 - Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

AU - Ai, Hua

AU - Flask, Christopher

AU - Weinberg, Brent

AU - Shuai, Xintao

AU - Pagel, Many D.

AU - Farrell, David

AU - Duerk, Jeffrey

AU - Gao, Jinming

PY - 2005/8/18

Y1 - 2005/8/18

N2 - The development of super-paramagnetic polymer micelles as a new class of magnetic resonance imaging (MRI) probes with high spin-spin relaxivity and sensitivity, was reported. The micelles consists of a cluster of hydrophobic magnetite particles encapsulated inside the hydrophobic core of polymeric micelle whose surface is stabilized by a poly(ethylene glycol) (PEG) shell. The unique core-shell composite design helps to achieve an ultrasensitive MRI detection limit of 5.2 μgmL-1, and promises for an application in molecular imaging and image-visible drug delivery applications. An amphiphilic diblock copolymer of poly(η-caprolactone)-b-polyethylene glycol was used in the study.

AB - The development of super-paramagnetic polymer micelles as a new class of magnetic resonance imaging (MRI) probes with high spin-spin relaxivity and sensitivity, was reported. The micelles consists of a cluster of hydrophobic magnetite particles encapsulated inside the hydrophobic core of polymeric micelle whose surface is stabilized by a poly(ethylene glycol) (PEG) shell. The unique core-shell composite design helps to achieve an ultrasensitive MRI detection limit of 5.2 μgmL-1, and promises for an application in molecular imaging and image-visible drug delivery applications. An amphiphilic diblock copolymer of poly(η-caprolactone)-b-polyethylene glycol was used in the study.

UR - http://www.scopus.com/inward/record.url?scp=23944490445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944490445&partnerID=8YFLogxK

U2 - 10.1002/adma.200401904

DO - 10.1002/adma.200401904

M3 - Article

AN - SCOPUS:23944490445

SN - 0935-9648

VL - 17

SP - 1949

EP - 1952

JO - Advanced Materials

JF - Advanced Materials

IS - 16

ER -

Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this