Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis

Yanyong Xu; Yang Xu; Yingdong Zhu; Huihui Sun; Cody Juguilon; Feng Li; Daping Fan; Liya Yin; Yanqiao Zhang

doi:10.1016/j.ymthe.2019.09.008

Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis

Yanyong Xu
, Yang Xu
, Yingdong Zhu
, Huihui Sun
, Cody Juguilon
, Feng Li
, Daping Fan
, Liya Yin
, Yanqiao Zhang

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Atherosclerosis is the leading cause of death in Western countries. Zhang and colleagues show that microRNA-34a (miR-34a) plays a key role in regulating macrophage cholesterol efflux, inflammation, and atherosclerosis. They also show that antagonism of miR-34a promotes regression of atherosclerosis and improves metabolic homeostasis.

Original language	English (US)
Pages (from-to)	202-216
Number of pages	15
Journal	Molecular Therapy
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.ymthe.2019.09.008
State	Published - Jan 8 2020
Externally published	Yes

Keywords

ABCA1
ABCG1
atherosclerosis
cholesterol efflux
inflammation
LXR
miR-34a

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

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10.1016/j.ymthe.2019.09.008

Cite this

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title = "Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis",

abstract = "Atherosclerosis is the leading cause of death in Western countries. Zhang and colleagues show that microRNA-34a (miR-34a) plays a key role in regulating macrophage cholesterol efflux, inflammation, and atherosclerosis. They also show that antagonism of miR-34a promotes regression of atherosclerosis and improves metabolic homeostasis.",

keywords = "ABCA1, ABCG1, atherosclerosis, cholesterol efflux, inflammation, LXR, miR-34a",

author = "Yanyong Xu and Yang Xu and Yingdong Zhu and Huihui Sun and Cody Juguilon and Feng Li and Daping Fan and Liya Yin and Yanqiao Zhang",

note = "Publisher Copyright: {\textcopyright} 2019 The American Society of Gene and Cell Therapy",

year = "2020",

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day = "8",

doi = "10.1016/j.ymthe.2019.09.008",

language = "English (US)",

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T1 - Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis

AU - Xu, Yanyong

AU - Xu, Yang

AU - Zhu, Yingdong

AU - Sun, Huihui

AU - Juguilon, Cody

AU - Li, Feng

AU - Fan, Daping

AU - Yin, Liya

AU - Zhang, Yanqiao

PY - 2020/1/8

Y1 - 2020/1/8

N2 - Atherosclerosis is the leading cause of death in Western countries. Zhang and colleagues show that microRNA-34a (miR-34a) plays a key role in regulating macrophage cholesterol efflux, inflammation, and atherosclerosis. They also show that antagonism of miR-34a promotes regression of atherosclerosis and improves metabolic homeostasis.

AB - Atherosclerosis is the leading cause of death in Western countries. Zhang and colleagues show that microRNA-34a (miR-34a) plays a key role in regulating macrophage cholesterol efflux, inflammation, and atherosclerosis. They also show that antagonism of miR-34a promotes regression of atherosclerosis and improves metabolic homeostasis.

KW - ABCA1

KW - ABCG1

KW - atherosclerosis

KW - cholesterol efflux

KW - inflammation

KW - LXR

KW - miR-34a

UR - https://www.scopus.com/pages/publications/85073000415

UR - https://www.scopus.com/pages/publications/85073000415#tab=citedBy

U2 - 10.1016/j.ymthe.2019.09.008

DO - 10.1016/j.ymthe.2019.09.008

M3 - Article

C2 - 31604677

AN - SCOPUS:85073000415

SN - 1525-0016

VL - 28

SP - 202

EP - 216

JO - Molecular Therapy

JF - Molecular Therapy

IS - 1

ER -

Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis

Abstract

Keywords

ASJC Scopus subject areas

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