Macrophage migration inhibitory factor (MIF) in the development and progression of pulmonary arterial hypertension

Mohamed Ahmed, Edmund Miller

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Macrophage migration inhibitory factor (MIF) has been described as a pro-inflammatory cytokine and regulator of neuro-endocrine function. It plays an important upstream role in the inflammatory cascade by promoting the release of other inflammatory cytokines such as TNF-alpha and IL-6, ultimately triggering a chronic inflammatory immune response. As lungs can synthesize and release MIF, many studies have investigated the potential role of MIF as a biomarker in assessment of patients with pulmonary arterial hypertension (PAH) and using anti-MIFs as a new therapeutic modality for PAH.

Original languageEnglish (US)
Article number14
JournalGlobal Cardiology Science and Practice
Volume2018
Issue number2
DOIs
StatePublished - 2018
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this