Lysosomal acid lipase deficiency: A form of non-obese fatty liver disease (NOFLD)

Hassan H. A-Kader

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Introduction: With the growing obesity epidemic, nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the leading causes of liver disease worldwide. Although obesity is a main risk factor for the development of NAFLD, it can also develop in lean subjects and can be encountered in different clinical setting and in association with an array of genetic, metabolic, nutritional, infectious and drug-induced disorders. Areas covered: This article discusses causes of fatty liver in non-obese subjects focusing on Lysosomal acid lipase deficiency (LAL-D), a commonly overlooked disorder reviewing its prevalence, genetics, pathogenesis, clinical features, diagnosis and treatment. It will also review other causes of non-alcoholic fatty liver disease, which can be encountered in the absence of obesity and metabolic syndrome. Expert commentary: Although the prevalence of LAL-D has been estimated in the range of 1 in 40,000 and 1 in 300,000, this estimate is much more than the identified cases reported in the literature, which suggests that that the disease may be considerably under-diagnosed. There is a pressing need to educate clinicians about the disease, especially with the development of new promising therapeutic modalities.

Original languageEnglish (US)
Pages (from-to)911-924
Number of pages14
JournalExpert Review of Gastroenterology and Hepatology
Issue number10
StatePublished - 2017


  • LAL-D
  • Lysosomal acid lipase deficiency
  • Metabolic syndrome
  • NASH
  • Nonalcoholic fatty liver disease
  • Obesity

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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