TY - JOUR
T1 - Lysogeny in nature
T2 - Mechanisms, impact and ecology of temperate phages
AU - Howard-Varona, Cristina
AU - Hargreaves, Katherine R.
AU - Abedon, Stephen T.
AU - Sullivan, Matthew B.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Viruses that infect bacteria (phages) can influence bacterial community dynamics, bacterial genome evolution and ecosystem biogeochemistry. These influences differ depending on whether phages establish lytic, chronic or lysogenic infections. Although the first two produce virion progeny, with lytic infections resulting in cell destruction, phages undergoing lysogenic infections replicate with cells without producing virions. The impacts of lysogeny are numerous and well-studied at the cellular level, but ecosystem-level consequences remain underexplored compared to those of lytic infections. Here, we review lysogeny from molecular mechanisms to ecological patterns to emerging approaches of investigation. Our goal is to highlight both its diversity and importance in complex communities. Altogether, using a combined viral ecology toolkit that is applied across broad model systems and environments will help us understand more of the diverse lifestyles and ecological impacts of lysogens in nature.
AB - Viruses that infect bacteria (phages) can influence bacterial community dynamics, bacterial genome evolution and ecosystem biogeochemistry. These influences differ depending on whether phages establish lytic, chronic or lysogenic infections. Although the first two produce virion progeny, with lytic infections resulting in cell destruction, phages undergoing lysogenic infections replicate with cells without producing virions. The impacts of lysogeny are numerous and well-studied at the cellular level, but ecosystem-level consequences remain underexplored compared to those of lytic infections. Here, we review lysogeny from molecular mechanisms to ecological patterns to emerging approaches of investigation. Our goal is to highlight both its diversity and importance in complex communities. Altogether, using a combined viral ecology toolkit that is applied across broad model systems and environments will help us understand more of the diverse lifestyles and ecological impacts of lysogens in nature.
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U2 - 10.1038/ismej.2017.16
DO - 10.1038/ismej.2017.16
M3 - Review article
C2 - 28291233
AN - SCOPUS:85015218109
SN - 1751-7362
VL - 11
SP - 1511
EP - 1520
JO - ISME Journal
JF - ISME Journal
IS - 7
ER -