Lymphomatoid granulomatosis. Report of a case and review of the literature

Roger C. Bone, Mary Vernon, Richard E. Sobonya, Humberto Rendon

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


A 24 year old man had a nonproductive cough and chest pain. Chest roentgenogram showed a diffuse infiltrate, and pulmonary function studies showed restrictive lung disease. Extremity weakness, deteriorating mental status and neuropathy progressed as pulmonary findings diminished on corticosteroid therapy. Lung biopsy showed lymphomatoid granulomatosis. The neurologic status deteriorated despite treatment with Cytoxan®, intrathecal metnotrexate and brain irradiation. Autopsy showed mass lesions of lymphomatoid granulomatosis in the brain and healed lesions in the lungs. A review of the neurologic and pulmonary findings in reported cases show that diminution of pulmonary disease with progression of neurologic disease manifest by mass lesion is unusual. Since the etiology, prognosis and prevalence of this disease remains undefined, all patients with this disease should be reported on.

Original languageEnglish (US)
Pages (from-to)709-716
Number of pages8
JournalThe American journal of medicine
Issue number4
StatePublished - Oct 1978

ASJC Scopus subject areas

  • Medicine(all)


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